Genital Ulcer Dksease Flashcards
1
Q
herpes simplex virus (HSV)
A
- multiple painful genital ulcers (with a characteristic erythematous base), dysuria (likely due to irritation from the ulcers), tender lymphadenopathy (common with primary genital HSV infection), and systemic symptoms (fever, headache) in the setting of having a new sexual partner
- characteristic vesicles are often absent.
can be diagnosed using polymerase chain reaction (PCR), direct fluorescence antibody, viral culture (low sensitivity), or Tzanck smear (showing multinucleated giant cells).
Acyclovir is a guanosine chain analog that inhibits multiplication of herpes simplex virus, a double-stranded DNA virus.
2
Q
syphilis
A
- gram negative spirochete Treponema pallidum
- Single, painless ulcer at inoculation site with heaped-up borders & clean base followed by a rash and systemic symptoms
- Diagnostic tests: VDRL/RPR,
Dark-field microscopy - treated with penicillin, a bactericidal β-lactam antibiotic that works by inhibiting cell wall synthesis.
3
Q
Gonorrhea, caused by Neisseria gonorrhoeae
A
- common cause of urethritis, cervicitis, and pelvic inflammatory disease in sexually active females.
- Gram stain can reveal gram-negative diplococci
4
Q
Chancroid (due to Haemophilus ducreyi)
A
- Deep, purulent, painful ulcers with matted/suppurative lymphadenitis
- presents with purulent ulcers with “ragged” borders and suppurative
lymphadenopathy. - Gram stain may occasionally reveal gram-negative rods in a “school of fish” chain.
- Gram stain & culture
PCR
5
Q
Klebsiella granulomatis
A
Painless, progressive, red serpiginous ulcerative lesions without lymphadenopathy
- Gram stain & culture (difficult)
Biopsy (Donovan bodies)