GeneticsCYP-EO Flashcards
What is the heritability of GAD
30%
What is risk ratio of 1st degree relative with GAD to gen pop
6 x
What is risk ratio of 1st degree relative with ADHD to gen pop
2-8
What is risk ratio of 1st degree relative with schizophrenia to gen pop
10
What is risk ratio of 1st degree relative with BAD to gen pop
7-10
What is risk ratio of 1st degree relative with MDD to gen pop
3
What is risk ratio of 1st degree relative with OCD to gen pop
4
What is the heritability of schizophrenia
70-89
What is the heritability of BAD?
60-85
What is the heritability of MDD?
40
What is the heritability of OCD?
30-45
What is the heritability of ADHD?
75%
What is the prevalence of SUD in: 1 ASPD 2 BAD 3 Scz 4 MDD
1 -84%
2 -56%
3 -47%
4- 27%
What is the RR of substance use if:
One parent has SUD?
2 parents have SUD?
Father has ETOH and criminality?
2-4 for one parent
2-10 for 2 parents
9-18 if father
which antidepressant is a 2D6 substrat?
fluvoxamine Prozac Paxil Sertraline Duloxetine Venlafaxine Mirtazapine Trazodone Vortioxetine TCA (secondary and tertiary amines)
Which antipsychotics is a substrate of 2D6?
Haldol Olanzapine Risperidone Aripiprazole FGA
Which psychostimulants are substrate of 2D6?
Amphetamines (dexedrine and adderall)
Atomoxetine
Which class other than psychotropics are substrat of 2D6
Opioids (codeine methadone morphine)
B-blockers
Tamoxifen
Which meds are inducers of 2D6?
Rifampin
Phenytoin
Carbamaxepine
Which antidepressants are 2D6 inhibitors?
Prozac Paxil Dulox buproprion Sertraline es/citalopram TCA (tertiary and secondary amines)
Which antipsychotics are 2D6 inhibitors?
Abilify
Risperidone
Haldol
Which meds other than psychotropics are 2D6 inhibitors?
CBD Cocaine Methadone Amiodarone Quinidine Terbinafine
Which antidepressant is a 3A4 substrat?
Sertraline Fetzima Vilazodone Buspirone Trazodone TCA tertiary amines
Which antipsychotics are 3A4 substrats?
Abilify Lurasidone Seroquel Ziprasidone Haldol Clozapine (less than 1A2)
Which bezos are 3A4 substrats?
Alprazolam
Diazepam
Which meds other than psychotropics are 3A4 substrats?
Oxy Cocain Fentanyl Statines Tamoxifen
Which meds are 3A4 inducers?
St-John wart Modafinil Rifampin Phenytoin Phenobarb Carbamazepine/oxcarbamazepine Prednisone/glucocorticoids HIV meds
What inhibits 3A4?
Fluvoxamine Jus de pamplemousse Amiodarone Antifungals (azoles) THC/CBD HIV meds Macrolides (clarythro)
Which antidepressants are 1A2 substrats?
Fluvoxamine
Agomelatine
Mirtazapine
TCA (tertiary - clomi, amitr, imi)
Which antipsychotics are 1A2 substrats?
Clozapine
Haldol
Olanzapine
What other substance are 1A2 substrat?
Café
Warfarine
Methadone
Acetaminophene
Which susbstance induce 1A2?
Cigarette BBQ Modafinil Insuline Marijuana Choux de bruxelle Broccoli Phenytoine Rifampin Rifampin
Which substance inhibits 1A2?
Fluvox
Cimetidine
Amiodarone
Fluoroquinolones (cipro)
