Genetics of schizophrenia Flashcards
1
Q
Monozygotic concordances of schizophrenia
A
-41-65%
2
Q
Dizygotic concordances of schizophrenia
A
-0-28%
3
Q
Broad heritability of schizophrenia
A
80%
4
Q
NRG1
A
Neuroregulin
8p12-p21
5
Q
DTNBP1
A
Dysbindin
6p22
6
Q
G72
A
13q34
7
Q
DAAO
A
-interacts with G72
-D-amino acid oxidase
12q24
8
Q
RG24
A
- regulator of G protein signalling 4
- 1q21-22
9
Q
COMT
A
-catechol-o-methyl transferase
22q11
10
Q
DISC 1
A
- disrupted in schizophrenia
- 1q42
11
Q
Sham et al
A
-the morbid risk is greater among the relatives of those porbands who had an onset before rather than after age 21 years
12
Q
Downs syndrome
A
- the risk of schizophrenia is the same as or lower than the general population
- less than 0.6%
