Genetics of Common Hereditary Diseases (A)

Question 1

both genetics and environmental are involved

Answer 1

hypertension, cerebrovascular, CVS disorders, schizophrenia.,
DM

Question 2

Features of Multifactorial Diseases:

Answer 2

• Most affected children have normal parents.
• Recurrence risk increases with the number of affected children in a family.
• Recurrence risk increases with severity of defect. A more severely affected parent is more likely to produce an affected offspring.
• Most isolated congenital anomalies are multifactorial inheritance.
- consanguinity slightly increased the risk for an affected child.

Question 3

Neural tube defects is multifactorial inheritance determined by multile genetic and environmental factors

Answer 3

However, the impact of folic acid deficiency is exacerbated by a genetic mutation in MTHER (methylene tetrahydrofolate reductase).