genetics of common disorders/ personalized medicine

Question 1

how do you calculate relative risk?

Answer 1

prevalence of the disease in the relatives/ prevelence in the gen pop

Question 2

how do you calculate heritability

Answer 2

(variance in dizogotic twins/ variance in monozygotic twins)/ Variance in dizygotic pairs

Question 3

if a heritability equation gives you 0 what does that mean?

Answer 3

it means the cause if from something other than genetic probably enviromnetal

Question 4

what is characterisitic of incompletely penetrance mutations?

Answer 4

they usually skip a generation

Question 5

what is a multifactorial disease?

Answer 5

inheriting a disease phenotype that is attributable to two or more genes or due to an interaction with the environment

Question 6

what is meant by a polygenic disease

Answer 6

a disease phenotype that is determined by the combined action of multiple genetic loci

Question 7

what is the Warburg effect and what is it used for?

Answer 7

it is a way of imaging where in the body the most ATP is being used. So the Warburg effect basically looks for rapidly dividing cell by looking at where ATP is being used the most.