Genetics of breast cancer Flashcards
1
Q
What genes are associated with an increased risk of breast cancer?
A
BRCA1 and BRCA2
2
Q
Which chromosome is BRCA 1 on?
A
Chromosome 17
3
Q
What type of inheritance do BRCA1 and BRCA2 have?
A
Autosomal dominant inheritance
4
Q
Which chromosome is BRCA2 on?
A
Chromosome 13
5
Q
By how much does the BRCA1 gene increase the chance of developing breast cancer?
A
60-85%
6
Q
By how much does the BRCA2 gene increase the chance of developing breast cancer?
A
40-85%
7
Q
What do men with the BRCA2 gene have an increased risk of developing?
A
6% chance of developing breast cancer (100x more than general population)
