Genetics of ageing Flashcards
1
Q
What is the essence of ageing?
A
random mononuclear damage during cell replication
inactivity, poor diet and inflammation increase damage
2
Q
What is the Hayflick limit?
A
supposed limit to ageing however most cells don’t divide enough times for this to be a limiting factor
3
Q
What shortens with each replication?
A
telomeres - TTAGG
4
Q
What does the shortening of telomeres lead to?
A
cell senescence (stop dividing)
5
Q
What is the role of telomerase?
A
can reextend the shortened telomeres
6
Q
What is the disposible soma hypothesis?
A
balancing the energy it takes to repair the body with the burden of having the damage
