Genetics Flashcards
What is the mode of inheritance of MODY?
Autosomal dominant
Is MODY insulin-dependent or insulin-independent?
Insulin-independent
What is the typical age of onset for MODY?
Age
What is the most common cause of MODY and what type is this?
Transcription factor mutations to HNF1α (MODY3)
What is the second most common cause of MODY and what type is this?
Glucokinase mutations (MODY2)
What type of MODY has the greatest rise in glucose is untreated?
MODY3
What type of MODY sees glucose rise at a similar rate to normal as we age, albeit at a higher level?
MODY2
What type of MODY shows worse glucose tolerance on OGTT; MODY2 or MODY3?
MODY3
When does MODY2 present?
At birth
What sort of hyperglycaemia does MODY2 have?
Stable
How is MODY2 treated?
Diet
When does MODY3 present?
Adolescence
What sort of hyperglycaemia does MODY3 have?
Progressive
How is MODY3 treated?
One third -> Diet
One third -> SUs
One third -> Insulin
In what type of MODY are complications most common?
MODY3
