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Addiction Medicine Boards > Genetics > Flashcards

Genetics Flashcards

1
Q

Gene linked to greater reduction in drinking with naltrexone

A

OPRM-1

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2
Q

Gene involved with smoking cessation & pharmacotherapy

A

CHRNA5

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3
Q

Gene for etoh metabolism; risk of GI cancer

A

ALDH1B + ALDH2

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4
Q

Gene for amygdala activation and psychiatric issues in alcohol abuse

A

SLC6A4

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5
Q

Gene for alcohol flushing

A

GABRA6, ALDH2

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6
Q

Gene for smoking relapse

A

CYP2A6

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7
Q

Gene linked to circadian rhythm and cocaine addiction

A

PER1

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8
Q

Gene involved in cocaine induced paranoia

A

VNTR

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9
Q

Gene for cocaine addiction

A

CAMK4

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10
Q

Gene with lower change of cocaine addiction

A

CHRNA5

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11
Q

Gene carrying frontal lobe differences leading to AUD

A

AUTS2

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12
Q

Gene involved in efficacy of methadone

A

OPRD1

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13
Q

Gene involved in non responsiveness to MAT

A

ALDH5A1

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14
Q

Gene involved in increased resp. depression with codeine

A

CYP2D6

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15
Q

Gene linked to withdrawal and craving in THC

A

FAAH

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16
Q

Gene with higher risk of smoking, lower risk of cocaine

A

CHRNA5

17
Q

AA sub in OPRM-1 that leads to increased risk of alcohol relapse

A

arginine –> aspartic acid

18
Q

associated with alcohol dependence and alcohol-related reward processes

A

GABR2

19
Q

gene linked to epigenetic changes in those with ACEs

A

ALDH1A1

20
Q

gene that encodes the CB1 receptor

A

CNR1

21
Q

gene involved in respiratory depression with use of codeine

A

CYP2D6

22
Q

gene involved in opioid addiction relapse

A

ALDH5A1

23
Q

def of metabotropic receptors

A

receptors distant to ion channel–2nd messenger

24
Q

project MATCH: angry patients did better with

A

MET

25
Q

project MATCH: those with little support for abstinence better with

A

12-step facilitation

26
Q

project MATCH: more severe SUD did better with

A

12-step facilitation

27
Q

project MATCH: less severe SUD did better with

A

CBT

28
Q

gene assoc with increased number of cigarettes

A

CYP2A6*1B

29
Q

most likely linked to CUD

A

CNR1

Addiction Medicine Boards (5 decks)

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