Genetics Flashcards
Gene linked to greater reduction in drinking with naltrexone
OPRM-1
Gene involved with smoking cessation & pharmacotherapy
CHRNA5
Gene for etoh metabolism; risk of GI cancer
ALDH1B + ALDH2
Gene for amygdala activation and psychiatric issues in alcohol abuse
SLC6A4
Gene for alcohol flushing
GABRA6, ALDH2
Gene for smoking relapse
CYP2A6
Gene linked to circadian rhythm and cocaine addiction
PER1
Gene involved in cocaine induced paranoia
VNTR
Gene for cocaine addiction
CAMK4
Gene with lower change of cocaine addiction
CHRNA5
Gene carrying frontal lobe differences leading to AUD
AUTS2
Gene involved in efficacy of methadone
OPRD1
Gene involved in non responsiveness to MAT
ALDH5A1
Gene involved in increased resp. depression with codeine
CYP2D6
Gene linked to withdrawal and craving in THC
FAAH
Gene with higher risk of smoking, lower risk of cocaine
CHRNA5
AA sub in OPRM-1 that leads to increased risk of alcohol relapse
arginine –> aspartic acid
associated with alcohol dependence and alcohol-related reward processes
GABR2
gene linked to epigenetic changes in those with ACEs
ALDH1A1
gene that encodes the CB1 receptor
CNR1
gene involved in respiratory depression with use of codeine
CYP2D6
gene involved in opioid addiction relapse
ALDH5A1
def of metabotropic receptors
receptors distant to ion channel–2nd messenger
project MATCH: angry patients did better with
MET
project MATCH: those with little support for abstinence better with
12-step facilitation
project MATCH: more severe SUD did better with
12-step facilitation
project MATCH: less severe SUD did better with
CBT
gene assoc with increased number of cigarettes
CYP2A6*1B
most likely linked to CUD
CNR1
