Genetic Transmission

Question 1

What is a pseudodominance? give an example

Answer 1

If allele frequency is high, it will not be rare for a homozygote to have a heterozygous partner; e.g., hemochromatosis.

Question 2

How can you recognize the X-linked pedigree?

Answer 2

No male to male transmission

Question 3

What is locus heterogeneity?
What is** allelic** heterogeneity?

Answer 3

Question 4

What is Epistasis? give an example

Answer 4

Gene interaction results in
modification of phenotype

A child with AB blood phenotype, parents A and O

Question 5

Give an example of imprinted pedigree, what do you see in the pedigree?

Answer 5

Hereditary paraganglioma

The phenotype is expressed only if the allele is transmitted from a male

Question 6

Calculation for mutation selection balance for AR

Answer 6

Calculation for mutation selection balance for AD

Question 7

coefficinet of inbreeding between first cousins are…..
between brothers and sisters are…..
between uncle and niece is…..

Answer 7

1/16
1/4
1/8