Genetic Linkage And Gene Mapping Flashcards

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1
Q

How is linkage broken

A

Crossing over

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2
Q

Does linkage follow mendels law

A

No

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3
Q

Frequency of recombination formula

A

Frequency of recombination= no of recombinant ×100/total no of progeny

1% recombination - 1 cell out of 50

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4
Q

Cis and trans configuration of homologous chromosome

A

Cis/coupling- linked genes on each chr are of same type- AB or ab
Trans/repulsion -linked genes on each chr are of different types Ab or aB

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5
Q

Difference between recombination frequency of cis and trans configuration of homologous chr

A

Same

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6
Q

Genetic mapping and what does it tell and unit

A

It shows relative location of gene on chr. It is based on linkage
Made by using frequency of crossing over

It tells
Gene order and gene distance

Unit cM(centi morgan)
cM/map unit=frequency
3.5%=3.5cM

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7
Q

1cM= how many base pairs

A

10^6

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8
Q

Hot and cold spot on crossing over

A

Hot- more no of recombinant hotspot

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9
Q

How to identify if gene are linked or unlinked

A

If unlinked all phenotype class should be in equal no

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10
Q

Gene distance formula

A

No of single cross over+ double cross over×100/total progeny

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11
Q

Purpose of two point cross and three point cross

A

Two point cross- tells gene distance
Three point cross- tells gene order

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