Genetic explanations of Schizophrenia A01

Question 1

What did Gottesman’s (1991) analysis of the genetic component of Sz show?

Answer 1

He found that the more related you are to someone with Sz, the higher chance you have of getting it.

The concordance rates for Monozygotic twins are high (48%)

However, there is room for environmental influences (nurture)

Question 2

Is Schizophrenia polygenic?

Answer 2

Yes

Question 3

What did Stephen Rike (2014) do in his combined research conducted on genome-wide studies?

Answer 3

The genetic makeup of 37,000 patients with Sz was compared to the genetic makeup of 113,000 controls without the disorder

Question 4

What did Stephen Rike (2014) find?

Answer 4

108 separate genes which were associated with a slightly increased risk of Sz

Question 5

What did Brown (2002) find?

Answer 5

The risk of schizophrenia increases from around 0.7% with fathers under 25 to over 2% in fathers over 50