Genes of Embryogenesis- from First Aid

Question 1

What does the sonic hedgehog gene do for embryogenesis?

Answer 1

• A-P patterning
• CNS development

Question 2

What does a mutation in the sonic hedgehog gene cause in the fetus?

Answer 2

holoprosencephaly

Question 3

What does the Wnt-7 gene do for embryogenesis?

Answer 3

organizes dorsal-ventral axis

Question 4

Where in the embryo is the sonic hedgehog gene produced?

Answer 4

at the base of limbs in zone of polarizing activity

Question 5

In the embryo, this is produced at the base of limbs in zone of polarizing activity.

Answer 5

sonic hedgehog gene

Question 6

Where in the embryo is the Wnt-7 gene produced?

Answer 6

at the apical ectodermal ridge (distal end of each developing limb)

Question 7

What does the FGF gene do for embryogenesis?

Answer 7

stimulates mitosis of underlying mesoderm –> lengthening of limbs

Question 8

In the embryo, this stimulates mitosis of underlying mesoderm –> lengthening of limbs.

Answer 8

FGF gene

Question 9

In the embryo, this is necessary for A-P patterning and CNS development.

Answer 9

sonic hedgehog gene

Question 10

What does the homeobox (Hox) genes do for embryogenesis?

Answer 10

segmental organization in cranio-caudal direction

Question 11

What does a mutation in the homeobox (Hox) genes cause?

Answer 11

appendages are in the wrong locations

Question 12

In the embryo, this is necessary for segmental organization in the cranio-caudal direction.

Answer 12

homeobox (Hox) genes

Question 13

In the embryo, this organizes the dorsal-ventral axis.

Answer 13

Wnt-7 gene

Question 14

What causes multiple endocrine neoplasia (MEN) 2A?

Answer 14

a mutation of germline RET (neural crest cells)

Question 15

A mutation of germline RET (neural crest cells) causes what syndrome?

Answer 15

multiple endocrine neoplasia (MEN) 2A