Genes and things

Question 1

PDGF Receptor

Answer 1

Proto-oncogene

Platelet derived growth factor receptor

When over active drives cell growth

Question 2

p53

2 functions

Answer 2

Tumour supressor gene

Cell cycle checkpoint protein
Inducer of apoptosis

Question 3

pRb

Answer 3

Tumour supressor gene

Cell cycle checkpoint protein

Question 4

2 e.g of cell cycle checkpoint proteins?

Answer 4

pRb
p53
(these are tumour supressors)

Question 5

2 e.g. of growth/developmental supressors

Answer 5

TGFbeta

patched 1

Question 6

CDKI

Answer 6

Tumour supressor gene

Cell cycle inhibitor

Question 7

2 e.g. of cell cycle inhibitors

Answer 7

CDKI

p16

Question 8

2 e.g. of inducers of apoptosis

Answer 8

Bax

p53

Question 9

BAX

Answer 9

Tumour supressor

induces apoptosis

Question 10

e.g. of DNA repair enzyme

Answer 10

Xerderma pigmentosa

Question 11

e.g. of developmental pathways

Answer 11

patched (Hh pathway)

Loss of function of pachted1 allows cell proliferation in the absence of Hh

Question 12

2 e.g. of inherited predispositios

Answer 12

APC (part of Wnt pathway) - precancerours intestinal polyps

BRACA1 - 60% probability of breast cancer