CE L1 Intro - Hallmarks of cancer and targeting methods

Question 1

10 Hallmarks of cancer:

Answer 1

1. Evading growth suppressors
2. Immune destruction avoidance
3. [Enable replicative] immortality
4. [Tumor promoting] inflammation
5. [Activating] invasion & metastasis
6. Angiogenisis
7. Instability of genome
8. Resisting cell death
9. Deregulating cellular energetic
10. Sustaining proliferation signalling

Question 2

1. Evading growth suppressors

Answer 2

Cyclin dependant kinase inhibitors

Question 3

2. Immune destruction avoidance

Answer 3

Immune activating anti-CTLA4mab

Question 4

3. [Enable replicative] immortality

Answer 4

Telomerase inhibitors

Question 5

4. [Tumor promoting] inflammation

Answer 5

Selective antiinflammatory drugs

Question 6

5. [Activating] invasion & metastasis

Answer 6

Inhibitors of HGF/c-Met

Question 7

6. Angiogenisis

Answer 7

Inhibitors of VEGF signalling

Question 8

7. Instability of genome

Answer 8

PARP inhibitors

Question 9

8. Resisting cell death

Answer 9

Proapoptotic BH3 mimetics

Question 10

9. Deregulating cellular energetic

Answer 10

Aerobic glycolysis inhibitors

Question 11

10. Sustaining proliferation signalling

Answer 11

EGFR inhibitors

Question 12

You should be able to name at least 3 examples

Answer 12

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