General Side Effects

Question 1

Serotonin Syndrome

Answer 1

Confusion, flushing, diaphoresis, tremor, myoclonic jerks, hyperthermia, hypertonicity, rhabdomyolysis, renal failure, death

Question 2

Hypertensive Crisis

Answer 2

build up of stored catecholamines (NE, Epi, Dopa)

MAOIs + tyramine foods (red wine, cheese, fava beans, chicken liver, cured meats) or + sympathomimetics

Question 3

EPS

Answer 3

parkinsonism, akathisia, dystonia
traditional antipsychotics/neuroleptics
treat with benzotropine

Question 4

Tardive Dyskinesia

Answer 4

clozapine may help improve

Question 5

NMS

Answer 5

fever, tachycardia, htn, tremor, increased CPK, “lead pipe” rigidity
antipsychotics (typical > atypical)
20% mortality

Question 6

HAM

Answer 6

TCAs, low potency antipsychotics
H - sedation, wt gain
A - hypotension, dizziness, reflex tachycardia
M - dry mouth, blurred vision, urinary retention