general q's Flashcards
Ion channel coupled receptors
entry of positive ions cause depolarisation which causes cell activation
Which drug can be used as a premedication to dry up secretions of saliva and bronchiol mucus?
Hyoxine
Asthma
Mast cells - IgE
An example of a folate antagonist?
Methotrexate
Full agonists have a
high efficacy
Antagonists have an efficacy of
0
Partial agonists have an efficacy of
less than 1
What produces thyrotrophin releaseing hormone?
Hypothalamus
Prazosin is a competitive reversible antagonist at alpha-adrenoceptor
- used in cardiovascular disease
- prevents contraction of smooth muscle in blood vessel wall
- makes blood vessels dilate
Active transport is:
- concentrative
- uni-directional
Adrenal medulla secretes:
epinephrine
-failure of adrenal medulla can cause hypotension
Adrenaline
maintains blood pressure through ionotropic effects
RECEPTORS
- are proteins, often glycoproteins or lipoproteins
- can be up regulated or down regulated
- are saturable
- have more than one binding site
Intracellular cell signalling molecules include:
- calcium ions
- cAMP
- PIP3
Coronary artery occlusion by vasospasm is found in which type of angina?
Variant angina
Treat hypothyroidism with
iodides
Cyclophosphamide
-alkylating agent which is activated in the liver
Nuclear receptors:
- are soluble proteins
- are localised with the cytoplasm
- attach to DNA in the promoter regions of genes
Neurotransmitters are
paracrine signals
Tubocuranine
skeletal muscle relaxant in surgery
- act on ACh nicotinic receptors
- can be reversed by inhibiting ACh
Glucocorticoids
eg beclomethasone
-inhibit phospholipase A2
-too much glucocorticoids can lead to osteoporosis
-
