General Pharmacology of Parkinson’s Disease

Question 1

Whats the Goal for Pharmacological drugs for PD?

Answer 1

Primary: Restore DAergic neurotransmission Secondary: Inhibit Cholinergic neurotransmission

Question 2

What are the types of drugs used in PD?

Answer 2

Levodopa (L-Dopa) Dopaminergic Receptor Agonists Monoamine Oxidase (MAO) Inhibitors Anticholinergics Amantadine

Question 3

What is the cause of early PD?

Answer 3

genetic factors mutation of parkin

Question 4

Which h drug used in early onset PD?

Answer 4

Dopamine agonists- they have lower motor complications Levodopa and MAO-B is reserved for patients over 60

Question 5

When is late onset PD?

Answer 5

over 60

Question 6

What are the drugs used in late onset PD?

Answer 6

L-DOPA Dopamine agonist COMT MAOB all are moderate degree of symptom control, first choice and to reduce motor complications

Question 7

What are the target sites for PD agents?

Answer 7

Target sites include: peripheral metabolism of L-Dopa (enzyme inhibitors of DDC and MAO), presynaptic terminal (L-Dopa), glial metabolism of L-Dopa (enzyme inhibitors of MAO), and striatal dopamine receptors (D1 & D2- Dopamine agonists).

Question 8

Genral approach to PD managements

Answer 8