Amantidine

Question 1

What is Amantidine?

Answer 1

Antiviral drug with anti-Parkinsonian properties

Question 2

What is the MOA of Amantidine?

Answer 2

• May modulate dopaminergic function by indirectly modifying
  DA synthesis, release, or uptake or on DA receptors (direct)
  
  • INHIBITS N-methyl-D-aspartate (NMDA) receptors

Question 3

What are therapeutic effects of Amantidine?

Answer 3

Modest benefit for tremor, rigidity and bradykinesia (Early
onset or Mild PD Symptoms)
- Use: Reduce L-DOPA induced dyskinesias (via NMDA)

Question 4

What are the adverse effects of Amantidine?

Answer 4

Primarily CNS = restlessness, depression, irritability,
insomnia, agitation, excitement, hallucinations, confusion
- Overdoses = acute toxic psychosis
- Others = headache, edema, postural hypotension, heart failure, GI disturbances.