General Pharmacology Flashcards
Neuromuscular blocking agent with hepatic metabolism and active metabolite?
Vecuronium
80% active
Hypermagnesemia
EKG Prolonged PR interval QRS duration QT interval
Fatigue nausea headache disminished deep tendon reflex
Inhaled anesthetics gas:blood partition coefficient
Larger coefficient means that the gas has a higher solubility in the blood but slower onset of action
Isoflurane 1.46
Sevoflurane 0.65
Desflurane 0.42
Diuretics ; hydrochlorothiazide
Tiazide diuretics
Inhibit NA/CL transport in distal convoluted tube
Inhibition of NA reabsorption
AE: hyponatremia hypochloremic alkalosis hypokalemia HYPERcalcemia HYPERglycemia
Methahemoglobinemia
Tto: methylene blue 1-2 mg/kg converts fe3-fe2+
Cause : local anesthetics metoclopramida nitritos
Ferrous —> ferric (Fe3+)
Cianosis: unable to bind 02
Pao2 levels are normal pulsooximetro 85-88%
Precurarization dose
10% of ED95 3-5 days before sch
Rocuronio 0.03 mg/kg
Prevents augmentation if intrabdoninal pressure
Fasciculation
Need to increase succinylcholine dose : 1.5 mg/kg
Not alteration in intraocular pressure or K release
ED95 of neuromuscular blocker’s
ED 95 : dose that cause 95% twitch suppression in 50% of population
Rocurronium : 0.3 mg/kg. ID: 2-4 x
Vecuronium : 0.05 mg/kg. ID: 2-4x
Cisatracurium : 0.05mg/kg. ID: 3-5x
Pancuronium : 0.07mg/kg. ID 1-1.5 x
Dantrolene dose
2.5mg/kg 3-5 min
Repeat 2-3 mg/kg 15 minutes
Hypocalcemia
Symptoms: carpal spasm
Tingling around lips
Qx 24-48 hours
EKG QT prolongation
PR short
Inversion of T wave
EKG and electrolytes
hyPeR”, where hyperkalemia/calcemia/magnesemia leads to PRolongation of the PR interval. The opposite tends to occur with the QT interval for each electrolyte
Vasopresin
Reabsorption of water and sodium in colleting ducts
Hypercalcemia
EKG P-R prolonged Q-T short
Hyperkalemia
> 5.2
EKG PR prolongation QT shortened T spike (earliest ) QRS widening
AV NODAL BLOCK SINUS BRADYCARDIA
