general pharmacodynamics Flashcards
describes the action of drug on body
pharmacodynamics:(what does the drug do on the body
how the body react with the drug
pharmacokinetics
describe Pharmacokinetics
ADME
A: absorbtion
D: distribution
M: metabolism
E: execration
Drug+ receptor
biological action
specific therapy
cure diseases
symptomatic thearpy
decrease symptoms
prophylactic therapy
prevent diseases
supportive therapy
maintain general condition
Replacement therapy
replete deficiencies
Activate receptor
Agonist
InActivate receptor
Antagonist
oppsite reaction
Inverse Agonist
where does most of drugs bind to
receptors
what is the aim of of drugs
initiate biochemical reaction
where does the nicotinic receptors bind to
on the extracellular portion on binding site (LIGAND GATED CHANEL )
what does the nictonic do ?
open ion gated channel
works in muscle contraction and neurotrasmission
describe the mechanism of G coupled receptors ?
When the extracellular portion is binded which activate the intracellular g protien
the G protein composed of a subunits which has the GTP
and b and y subunits which anchor the G protein inn cell membrane
describe the mechanism of enzyme linked receptors
cause conformational changes that rise the cytosolic enzyme activity
phosphorylates tyrosine residues on itself and other proteins
phosphorylation modify target protein structure and acts as molecular switch
eg: Intracellular receptors
steroids.
how does the steroids works
diffuse inside the cells
bind to transcription factors
and activate or in activate causes thaetranscription of DNA into RNA and translation of RNA into protein
degree which the drug able to produce the desired response
efficacy
amount of drug required to produce 50% of the maximal response
potency
What does the potency used for ?
compare compounds within classes of drugs
concentration of the drug which induces a specified clinical effect in 50% of the subject
Effective does concentration 50% (ED50 or EC50 )
