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Pathology > General Pathology > Flashcards

General Pathology Flashcards

1
Q

Causes of cellular injury?

A

Most common cause is hypoxia (m/c is ischemia)
Most severe is ischemia
Radiation
Drugs
Infection
Autoimmune disorder
Nutritional disease
Genetic factors

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2
Q

Most sensitive to hypoxia
Least sensitive to hypoxia?

A

Most: neurons
Least: skeletal muscles / fibroblasts

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3
Q

Factors affecting cell injury?

A

Type of cell
Metabolic state of cell
Duration of injury
Type of injury

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4
Q

Cellular responses to injury?

A

Cellular adaptation
Reversible cellular injury
Irreversible cellular injury
Cellular death
Intracellular accumulation
Pathological calcification

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5
Q

Hypertrophy mechanism, examples?

A

Increased cell size due to increased synthesis of protein
Occurs in permanent or non dividing cells
Physiological: uterine myometrium during pregnancy, breast during lactation, skeletal muscle in bodybuilding
Pathological: LVH,Bladder obstruction lead to proximal hypertrophy

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Pathology (4 decks)

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