General Medicine - Cardiology Flashcards
What is the pharmacological secondary prevention of MI?
ACEi + Statin + Beta-blocker + Dual platelet therapy ( aspirin + clopidogrel)
What is the Tetralogy of Fallot? What are the four constituents?
Group of four structural abnormalities of the heart that occur together.
- Pulmonary Stenosis
- Ventricular Septal Defect
- Overriding aorta
- Thick Right Ventricle
What is an atrial myzoma?
Non-cancerous tumour. Grows in the left or right inter-atrial septum.
Drugs for pharmacological cardioversion for AF?
- Flecainide/Amiodarone (if no known structural abnormality of the heart)
- Amiodarone ( if known structural abnormality)
ABCDE of Heart Failure on CXR
A - Alveolar oedema B- kerley B lines C- Cardiomegaly D- Dilated prominent upper lobe vessels E - Pleural Effusion
Guidelines for Pharmacological treatment of hypertension
FL- ACEi/ARB - if under 55 and not Black
CCB - if over 55 and Black
2nd - Thiazide- like diuretic (Eg - Indapamide)
3rd - Beta- blocker or alpha-blocker (if beta blocker CI, eg on salbutamol inhaler)
4th - Aldosterone antagonist (Spirinolactone) can be given if K+ < 4.5
What are Roth’s spots? Which condition do they present in?
Haemorrhages seen in the eye. Also called Litten’s sign.
Seen in Infective Endocarditis.
What criteria is used for the diagnosis of Infective Endocarditis?
Duke’s Criteria
Takayasu arteritis?
rare type of vasculitis. affects young Asian women. causes occlusion of aorta. usually presents with absent limb pulse. associated with renal artery stenosis. managed with steroids
What is the main cause of death in HCOM?
Ventricular arrhythmias
What can of inheritance pattern does HOCM follow?
Autosomal dominant inheritance pattern
What is a common side effect of beta blockers to warn patients about?
Insomnia/ difficulty sleeping
What kind of pulse is seen in aortic stenosis?
Slow rising pulse
What are the main causes of aortic stenosis in under 65s?
Bicuspid aortic valve
What is the main cause of aortic stenosis in over 65s?
Calcification of aortic valve
What is the time frame to classify an aortic dissection as acute?
If symptoms present within 14 days. More than that then it is chronic
What kind of Aortic Dissection indicates surgery?
Stanford Type A, or Type B where there is evidence of end organ ischaemia
Describe DeBakey Type 1 aortic dissection.
AD propagate from ascending aorta and external arch of the aorta (may continue distally)
Describe DeBakey Type 2 AD
AD confined to ascending aorta
Describe DeBakey Type 3 AD
AD limited to descending aorta
Describe Stanford A AD
AD involves ascending aorta and transverse aorta
Describe Stanford B AD
AD involves descending aorta only
How is Stanford B AD managed.
Managed with Beta-blockers and analgesia
Which kind of chest pain is relieved by sitting forward?
Pericarditis
How is chest pain relieved in Pericarditis?
Sitting forward
ECG changes in Pericarditis
Saddle shaped ST elevation
Which drug is beta-blockers never prescribed with and why?
Verapamil. Risk of cardiac death
Verapamil is never prescibed with which class of drug?
Beta-blockers
What is an Osbourne wave on ECG?
Positive deflection of J-point ( negative in aVR and V1)
Which electrolytes cause ECG changes?
Calcium, magnesium and potassium
ECG changes in hypercalcaemia?
- Decrease QT interval
- Lengthened QRS interval
- Bradycardia
ECG changes in hypocalcaemia?
- Increased QT interval
2. decreased QRS interval
ECG changes in hyperkalaemia?
- pointed T-waves
- P-waves wider and reduced amplitude
- Increased PR interval
- ST elevation in V1-V3
- QRS wider
ECG changes in hypokalaemia?
- T wave wider and reduced amplitude
- ST depression
- P-wave increased
- U-waves present
ECG changes in hypermagnesemia?
Third degree heart block/ asystole
ECG changes in hypomagnesemia?
Arrhymthmias
What is the classification used for Heart Failure? How many stages are there?
New York Heart Association Classification.
4 stages
FL pharma treatment for angina prevention
Betablocker/ CCB
What two factors point to myocarditis?
New onset chest pain + recent viral illness
Interaction between phenobarbital and warfarin?
Phenobarbital induces CYP1A2 and reduces INR
Holter Monitor
24-48 hour ECG monitor. Used for patients who present with palpitations
Can Warfarin be taken while breast-feeding?
Yes
8 Reversible causes of Cardiac Arrest ( 4 Hs and 4 Ts)
4Hs - Hypothermia, Hypoxia, Hypovolaemia, Hypokalaemia/hyperkalaemia/hypocalcaemia
4Ts - Tension pneumothorax, thrombosis, toxins, tamponade
What is the Killip Classification used for?
Used to stratify risk of mortality post MI
Reasons for rhythm control in AF
- Coexistance of HF
- First onset AF
- Obvious reversible cause (Eg- Pneumonia)
What kind of breath sound can HF produce?
Polyphonic expiratory wheeze
Treatment of Torsade de Pointes
IV Magnesium sulfate
Presentation of Pulmonary hypertension
syncope, exertional angina, increase in sound of S2
Treatment for SVT
IV adenosine
Eisenmonger’s Syndrome
Eisenmenger’s syndrome is defined as the process in which a long-standing left-to-right cardiac shunt caused by a congenital heart defect (typically by a ventricular septal defect, atrial septal defect, or less commonly, patent ductus arteriosus) causes pulmonary hypertension and eventual reversal of the shunt into a cyanotic right-to-left shunt.
Treatment for major bleeding in patients on Warfarin
4 factor prothrombin complex concentrate 25-50 U/kg
ECHO findings in HCOM
MR SAM ASH - Mitral regurgitation, systolic anterior motion of anterior mitral valve leaflet, assymetrical hypertrophy
Presentation of HCOM
Young person - sudden colllapse, exertional angina, sudden death
Pansystolic murmur and low grade fever. Think?
infective endocarditis
Cause of third heart sound?
Normal is under 30 years old.
If not, left ventricular failure - dilated cardiomyopathy, constrictive pericarditis, mitral regurgitation
S1Q3T3 changes? which condition?
Saddle PE.
S1 - Prominent S-wave in lead 1
Q3 - Q-wave in lead 3
T3 - inverted T-wave in lead 3
Collapsing pulse seen in which condition?
Aortic regurgitation
Aortic stenosis symptoms pneumonic
SAD
Syncope
Angina (exertional)
Dyspnoea on exertion
Elderly and diabetic. Think?
Silent MI
Q-waves. Think?
Ongoing/ old MI
NICE guidelines for management of provoked VTE
Warfarin - 3 months, then assess
LMWH/Fondaparinux - continued for atleast 5 days or INR >/= 2 for at least 24 hours, if active cancer, continue for 6 months
V1 - V4, area and artery affected
Anteroseptal, LAD
2,3 avF, area and artery affected
Inferior, right coronary
V4-V6, 1, avL, area and artery affected
Anterolateral, LAD or left circumflex
1,avL +/- V5-V6, area and artery affected
Lateral, left circumflex
Tall R waves in V1-V2, area and artery affected
Posterior, left circumflex/ right coronary
Immediate management of suspected ACS.
- GTN
- Aspirin 300mg
- If O2 < 94%, then give O2
- ECG
Do not delay transfer to hospital
Warfarin target INRs?
VTE - 2.5, if recurrent = 3.5
AF - 2.5
Mechanical valves, depends on valve type,
mitral INR > aortic INR
If INR = 5-8, skip 1-2 doses, reduced subsequent maintainence dose
ECG change caused by Sotalol?
QT prolongation
Which factors affected by Warfarin?
2,7 9, 10
Emergency anticoagulation reversal?
Four factor prothrombin complex concentrate 25-5- U/kg + 5mg of Vit. K iv, if on warfarin, stop warfarin