GENERAL KNOWLEDGE ON DRUGS

Question 1

Darifenacin is used for:

Answer 1

It is used to treat an overactive bladder or urinary incontinence.

NB: It is M3 anti-muscarinic

Question 2

Pirenzepine is:

Answer 2

M1- muscarinic antagonist used to treat peptic, gastric and duodenal ulcers.

Question 3

Ipratropium and Tiotropium

Answer 3

Non-selective muscarinic antagonist used to treat COPD and asthma.

Question 4

Responses mediated by muscarinic receptors through G protein include;

Answer 4

Inhibition of Adenylate Cyclase
Stimulation of phosphoinositide specific phospholipids C
Activation of K+ channels (Directly)

Question 5

Direct acting Cholinergic Agonists:

Answer 5

Bethanechol
Methacholine
Pilocarpine
Carbachol

Question 6

Direct acting Cholinergic Agonists that acts only on muscarinic receptors:

Answer 6

Methacholine
Bethanechol
Pilocarpine

Question 7

Direct acting Cholinergic Agonists that act on muscarinic and nicotinic receptors:

Answer 7

Carbachol
Acetylcholine (from slide)

Question 8

Drugs used for treatment of open glaucoma:

Answer 8

Pilocarpine
Carbachol
Physostigmine(not so common)

Question 9

Drugs used for treatment of dry mouth and dry eyes;

Answer 9

Pilocarpine
Carbachol

Dry eyes and dry mouth Incase of SJOGREN’s syndrome

Question 10

Drugs used to increase GIT motility and bladder post operation/ post partum urinary retention:

Answer 10

Bethanechol
Neostigmine
Pyridostigmine

Question 11

Drugs used to diagnose COPD/ Asthma:

Answer 11

Methacholine

Question 12

Drugs used to diagnose myasthenia gravis:

Answer 12

Edrophonium (using Tensilon Test)

Question 13

Drugs used to treat Myasthernia gravis:

Answer 13

Neostigmine- short term
Pyridostigmine- chronic (long term)

Question 14

Selegiline and Iproniazid:

Answer 14

Monoamine oxidase(MAO) inhibitor