General Immunology

Question 1

Subdivisions of immune reactions

Answer 1

1. Cytotoxic -> virally infected (and stressed cells) e.g. NK killer cells (innate) and CTL
2. Type 1 -> intracellular pathogens
3. Type 2 -> mucosal/epithelial pathogens
4. Type 3 -> extracellular bacteria/fungi

Often occur together

Question 2

Type 1 immunity

Answer 2

• Elimination of intracellular (e.g. viral) pathogens
• Drives cytotoxicity

**Cytokine
**Interferon-y

**Innate cells
**ILC type 1 (innate lymhpoid cells) -> makes TNF, and IFN-y
Macrophages
NK cells

**Adaptive cell
**Th1

All make IFN-y

Question 3

Notes on Type 2 immunity

Answer 3

Emilination of mucosal/epithelial pathogens

**Cytokines
**IL 4, 5, 13

**Innate cells
**ICL 2
Eosinophils, basophils, mast cells

**Adaptive cells
**Th2 cells
B cells (to make IgE)

Question 4

Notes on Type 3 immunity

Answer 4

Elimination of extracellular bacteria/fungi

**Cytokines
**IL 17, 21, 22

**Innate cells
**ILC 3
Nuetrophils
Antimicrobial peptides (AMPS)

**Adaptive cells
**Th17 cells

Question 4

Notes on Type 3 immunity

Answer 4

Elimination of extracellular bacteria/fungi

**Cytokines
**IL 17, 21, 22

**Innate cells
**ILC 3
Nuetrophils
Antimicrobial peptides (AMPS)

**Adaptive cells
**Th17 cells

Question 4

Notes on Type 3 immunity

Answer 4

Elimination of extracellular bacteria/fungi

**Cytokines
**IL 17, 21, 22

**Innate cells
**ILC 3
Nuetrophils
Antimicrobial peptides (AMPS)

**Adaptive cells
**Th17 cells