Cytokines Flashcards
1
Q
Notes on tumour necrosis factor
A
Pro-inflammatory cytokine
Secreted by macrophages
Activates macrophages, acts as a costimulator for T cell activation, key mediator of response to gram negative septicaemia, similar properties to IL-1, anti-tumour effects (binds to p55 and p75 receptor which can induce apoptosis
Important in pathogensis of rheumatoid arthritis
**TNF Blockers
**Infliximab - monoclonal antibody, IV
Etanercept - fusion protein that mimics the inhibitory effects of naturally occuring soluble TNF receptors, SC
Adalimumab - monoclonal antibody, SC
Certolizumab
**Adverse effects
**Reactivation of latent TB
Demyelination
Infusion reactions
Cardiac failure
ANA positivity in 11% and reversible lupus like syndrome
