General Anesthetics - 8/26/15 (Haske) Flashcards
1
Q
Meyer-overton hypothesis
A
?
2
Q
higher lipid solubility =
A
higher potency
3
Q
Inhalation anesthetics work via what receptors?
A
GABAa receptors (produce IPSPs)
4
Q
MAC
A
minimum alveolar concetration @ 1 ATM that prevents movement during skin incision in 50%
5
Q
Increasing CO has what effect on IV/PO anesthesia? Inhalation anesthesia?
A
IV/PO: Faster induction
Inhalation: Slower induction
6
Q
Fa/Fi
A
?
7
Q
3 main factors determine uptake into blood
A
CO, solubility, partial pressure of gas
8
Q
More soluble drugs like Halothane will
A
take longer to reach equilibrium, compared to less soluble drugs (nitrous oxide)
9
Q
Does increased CO promote drug induction in brain?
A
No! Cerebral blood flow is regulated - CO should not bring extra agent into the brain
