General Flashcards
Non Modifiable causes of osteoporosis
Female
Ageing
Race eg Asian
Family history of maternal hip #
Modifiable risk factors for osteoporosis
Smoking
Low Dietary calcium
Lack of vitamin D
Alcohol > 2 std/day
Caffeine intake > 4cups/day
Physical inactivity
Medical causes of osteoporosis
Eating disorders Malabsorption eg coeliac disease Cushing’s Diabetes mellitus Hyperthyroidism Hyperparathyroidism Sex hormone deficiency Acromegaly Connective tissue disease eg RA Liver Failure Kidney Failure Heart failure
Drugs causing osteoporosis
Corticosteroids Antiepileptics eg phenytoin, carbamazepine Excessive thyroxine Breast Ca hormone therapy Prostate cancer hormone therapy Heparin Thiazolidinediones eg rosiglitazone
What is a T-score
Number of standard deviations above or below the mean bone density of a 30 yr old adult >= -1 =. Normal -1 - -2.5. Osteopenia
< -2.5 Osteoporosis
What is a z score
Number of standard deviations away from the mean BMD of age, gender and ethnicity matched controls. When z < 2.0 consider coexisting contributing factor
eg. Corticosteroid use, Hyperparathyroidism, Alcoholism.
Contraindications to HRT
Absolute:
Pregnancy
Current thromboembolism
Suspected or Active Oestrogen dependent tumour
Acute Ischemic Heart disease
Cerebrovascular disease
Undiagnosed vaginal bleeding
Active Liver disease
Active SLE
Relative (Seek Specialist Advice):
Previous Oestrogen Dependent Tumour (Breast, Ovary, Endometrial)
Increased risk of DVT/VTE
Previous Ischemic Heart Disease
Focal Migraine
Hypertriglyceridemia
Avoid in: Uncontrolled Hypertension and
Acute Intermittent Porphyria (progesterone)
Preconception care
Smoking cessation
Alcohol cessation
Weight and diet optimisation
Folate supplementation 0.5 or 5.0 (high risk) start 1/12 before pregnancy to end of first trimester.
Iodine supplementation 150 mcg. 220 mcg when breast feeding.
Physical activity 30 mins daily
Excessive gestational weight gain increases risk of: Gestational diabetes, preeclampsia, c-section, miscarriage, obese child (metabolic syndrome), large for dates. Weight loss is not recommended in pregnancy.
Contraindications Combined oral contraceptives
Absolute:
Pregnancy to 6 weeks post partum (if Breast feeding)
Previous DVT,
Previous oestrogen dependent tumour,
Previous stroke,
Uncontrolled Hypertension
Acute liver disease,
Migraine
35 yo w inc CVD risk (eg. smoking >15/day),
Immobilisation,
Chronic Liver disease,
SLE positive
Porphyrias
Contraindications to IUD
Absolute: Pregnancy, active PID, undiagnosed DUB, previous ectopic. Relative: Very large uterus, very small uterus, Anemia, immunodeficiency, impaired clotting, valvular heart disease, previous PID.
Hypertension in pregnancy: definitions
Hypertension: SBP > 140 or DBP > 90 Severe Hypertension: SBP > 160 or DBP > 110 Increase greater than 30/15 from baseline is concerning SBP > 170 = Urgent Treatment (referral) Timing usually after 20 weeks
Types of hypertension in pregnancy.
Preeclampsia = htn + end organ damage (usually proteinuria) Gestational Hypertension = new onset htn at > 20 weeks, resolving
Effects of smoking preconception
Male infertility Female infertility Delayed conception Delayed conception during assisted reproduction
Effects of smoking in pregnancy
Increased risk of: miscarriage, preterm birth (2x), placental problems (previa, abruption), preeclampsia, ectopic, foetal growth restriction, low birth weight, small for dated, birth defects
Effects of smoking on early childhood
Increased risk of: SIDS, T2DM, obesity, HTN, Nicotine dependence, ADHD, conduct disorder, psychiatric problems (eg Depression)
Alcohol in pregnancy
No level of alcohol is considered safe in pregnancy. Risks increase with quantity and frequency. Foetal alcohol spectrum: Facial abnormalities eg flat nasal bridge and epicanthal fold Impaired growth Abnormal structure and function of the nervous system and Foetal alcohol disorder Limb defects Intellectual and learning disabilities MSK defects Behavioural difficulties Poor social skills
Motivational Interviewing The 5 As
Ask Assess Advise Assist Arrange
Motivational interviewing Stages of change:
Precontemplative Contemplative Planning Action Maintenance Relapse
Motivational interviewing and intervention: Approach to education
- How big is the problem 2. Consequences of not doing/changing 3. Benefits of change 4. Barriers to change
Opportunistic screening
SNAP + Weight. All Depression. > 13 yo Chlamydia risk. 15 - 29 yo. Annual testing if sexually active Skin Cancer: opportunistic advice to All. self check > 12 yo, high risk = 3-12 mth screening, others opportunistic. Preconception care 15-49yo Colorectal Ca 50+, 2 yearly fobt CV risk: from 45+, (35yo ATSIC) every 2 years. Cholesterol 45+ (35yo ATSIC) every 1 - 5 years depending on risk. Bp from 18+ every 6 weeks to 2 years (high - low risk) Pap smear 18 - 69 or 2 years after sexually active. Every 2 years if normal. Mammogram 50 - 69 2 yearly. 40+ if 1st deg relative Dx
Stroke Risk ABCD2
Age >60 1pt BP > 140/90. 1pt Clinical features: unilateral weakness 2pt Speech impairment w. No weakness. 1pt Duration. > 60 min 2pt, 10 -59min. 1 pt Diabetes. 1pt Other high risk features: AF, 2 or more TIAs in 7 days (crescendo), carotid artery disease. High risk 4-7 immediate CT/MRI +/- Doppler Lower risk 0-3 CT head in 72 hrs
Ideal Weight gain in pregnancy
First trimester 0.5 - 2kg total 2nd - 3rd trimester BMI 30.0 0.2 kg/wk
Chronic Abdominal Pain Red flags
Older patient, Nocturnal Pain, Nocturnal diarrhoea, Progressive symptoms, Rectal bleeding, Fever, Anaemia, Weight loss, Abdominal mass, Faecal incontinence or urgency (recent onset),
Consider: pancreatic cancer, ovarian cancer, small and large bowel cancers, Mesenteric Ischemic, Crohn disease, metabolic disorder (eg lactase deficiency) If no red flags: Consider chronic appendicitis, adhesions, irritable bowel syndrome, Peptic ulcer,
Spondyloarthropathy types and features
Ankylosing spondylitis Reiter’s syndrome Psoriatic arthritis Enteropathic arthritis (Inflammatory Bowel Disease) Features: Chronic Systemic involvement + joint involvement sacroiliac joint involvement Affect areas around the joint including tendon attachments (esp knee, hip, foot)
Ankylosing spondylitis Features and treatment
Back +/- gluteal pain and stiffness causing early waking
Pain improves with mobilising
Weight loss, fever, fatigue
Reduced spinal flexion and extension (Schober’s test)
Uveitis (40%) due to HLA-B27 antigen
Age
M > F
Strong familial component
Vertebrae changes (syndesmophytes -> fusion -> bamboo spine)
Ix: Elevated CRP and ESR during acute inflammation Seronegative (RA -ve) ANCAs are oft +ve
HLA-B27 genotype
positive Schober’s test - clinical flexion (mark out 2 points 5cm below and 10 cm above L5. On touching toes should extend to >20 cm)
X-ray SI joints - early erosion and sclerosis. Spine - syndesmophytes -> bamboo spine
Tx: anti-inflammatory drugs eg indomethacin 100mg PR note (first line), cox-2 inhibitors (celecoxib) DMARDs eg sulfasalazine 500mg PO daily TNFa blockers eg. Inflixiamb
Reactive arthritis (Reiter’s syndrome) Common causes
Urogenital: Chlamydia trachomatis (male, 20 - 40yo) Enteric: Salmonella typhimurium, Shigella flexneri, Yersinia enteroclitica, Campylobacter jejuni Other: Streptococcal infections. Acute reactive arthritis may require prednisolone 25 mg daily Chronic reactive arthritis is managed as for ankylosing spondylitis
Viral Arthritis Causative organisms
Influenza Mumps Rubella Varicella Hepatitis B,C Epstein Barr Virus (esp myalgias) Cytomegalovirus Adenovirus (children) Ross River virus Barmah Forest virus Features: acute onset (within 10 days of viral illness), rash, polyarthritis, symmetrical inflammation, esp hands and feet, lymphopenia or lymphocytosis Terminates rapidly.
Arthritis Red flags
Fever Weight loss Profuse rash Lymphadenopathy Cardiac murmur Severe pain and disability Malaise and fatigue Vasculitic signs (palpable purpura, livedo reticularis, glomerulonephritis + Fever, wt loss, etc) Multi system involvement
Management of Spondyloarthropathies
eg: Psoriatic arthritis, Reactive arthritis, Enteropathis arthritis, Ankylosing spondylitis (adult and juvenile onset), and Unclassified spondyloarthritis.
Management:
Identify the most active elements of the disease and treat
Educate and reassure
Regular assessment and support
Genetic counselling esp ankylosing spondylitis + HLA-B27
Work and Posture advice
Physiotherapy referral
Occupational therapy referral
NSAIDs: Indomethacin 75 - 200mg PO or 100mg PR daily
DMARDs - Sulfasalazine 500mg daily
TNF-a inhibitors eg inflixamab
Complications of diverticulitis (6)
Bleeding Perforation Abscess Peritonitis Fistula (bladder, vagina, small bowel) Bowel obstruction
Red flags chronic Abdo pain
Progressively worsening symptoms
Recent Bowel changes eg incontinence
Weight loss
Fevers
Anaemia
PR bleeding
Abdominal mass
Nocturnal pain
Advanced age
Red flags for acute abdo pain
History: Progressively worsening vomiting Collapse at toilet (intraabdominal bleeding) Lightheaded Ischemic heart disease Distension Malignancy Signs: Fever Pallor Diaphoresis Hypotension Tachycardia or AF Prostration Rebound tenderness or guarding Decreased Urine output
ray Findings in Osteoarthritis
Joint space narrowing
Subchondral cysts
Ostophytes
Altered shape of bone ends.
Osteoarthritis
Principals of Management
Explanation
Exercise
Rest
Heat Packs, Heated blankets
Diet/Weight reduction
Mobility aids
Physiotherapy
Occupational therapy
Simple analgesics (Paracetamol)
NSAIDs (esp COX-2 if history or risk of GIT complications)
Glucosamine/Chondroiton
Surgery if severe.
Criteria for the diagnosis of Rheumatoid Arthritis
Symptom duration > 6 weeks
Early morning stiffnes > 1 hr
Arthritis in 3 + regions
Bilateral compression tenderness of the MTPs
Symmetrical involvement
RF +ve
Anti-CCP +ve
Bony erosions on xrays of hands or feet (late change)
Rheumatoid Arthritis: Principles of Management.
Patient education and support
Early treatment with DMARDs (methotrexate 5-10mg weekly + folate 5-10mg weekly) Can add sulfasalazine and/or hydrochloroquine if required, also infliximab.
Fish Oil 4g
Paracetamol, NSAIDS, Corticosteroids
Early referral to specialist
Regular functional assessment
Regular review
Regular Exercise
Physiotherapy referral
Occupational therapy referral
Daily joint mobilisation
Weight management
Gout Treatment
Acute:
NSAIDs eg indomethacin 50mg TDS 3-5 days then taper.
Colchicine 0.5mg q6h until pain relief (~24 hrs).
Corticosteroids: intra articular or oral (40mg daily for 4 days then wean to 10 days.
Chronic:
Allopurinol 100 - 300mg daily PO (lower doses if renal insufficiency)
Weight Reduction
Avoid purine rich food (eg organ meats)
Reduce alcohol intake
Water - 2 litres/day
Reduce sugary soft drinkss
Avoid diuretics and aspirin
Wear comfortable shoes.
Management of large congenital melanocytic naevi more than 20cm in diameter
Lifetime surveillance be undertaken whether or not any surgery has been performed. This could include baseline photography and three-monthly evaluation for the first year of life, followed by six-monthly evaluation for the next three years, and then yearly evaluation
Parents or patients report immediately any concerning changes that occur between follow-up visits
Biopsies be undertaken immediately of any areas which show suspicious features
Management of Cafe au Lait Macules
Solitary cALMs are common in up to 3% of healthy infants and 25% of children.
Multiple cALMs are rare in healthy children.
Children with three or more cALMs should be monitored for other features of NF-1
Most Children with six or more cALMs will eventually be diagnosed with neurofibromatosis-1 (NF-1), potentially affecting multiple organ systems.
Café au lait macules may also be seen in multiple other rare syndromes.
Treatment: Isolated cALMs may be treated with pigment laser therapy.
6 week baby check
How are family coping.
ANy Concerns
Jaundice, Colour, Birthmarks
Consider trisomy 21
Head Circumfrence, Lentgth, Weight and growth velocity
Engaging with examinars face
Eyes tracking, symetrical light reflections in eyes
Red eye reflex
cleft palate and uvula if able
Heart (ventriculo-septal defect, PDA) and lungs (central cyanosis, chest resesion, CCF, infection)
All limbs moving normally
Ventral suspension - head should be held inline with torso (serebral palsy)
Femoral Pulses (absent in coarctation of aorta)
decended testes, genital normality
Hip Dysplasia (Ortalani = downwards presure , Barlow = liftting, ie relocating)
Abdominal Pain and bowel changes in children
DDx
Most likely: Functional Gastrointestinal Disorder (50%) (eg IBS, Abdominal migraine, functional dyspepsia, childhood functional abdominal pain))
Must Exclude:
Coeliac Disease, IBD, Food Allergy, Eosinophilic Oesophagitis, Colorectal Cancer, Gastroenteritis.
Causes of Secondary Amenorrhoea
Pregnancy or contraception
PCOS
Hypothalamic-Pituitary axis disorder
Prolactinoma
Malabsorption
Thyroid disorder (Hyperthyroid, Hypothyroid)
Eating Disorder eg Anorexia nervosa
Strenuous exercise
Emotional Stress
Premature ovarian failure
Kidney Disease, Liver Disease
RACGP Exam lists as: Hypothalamic-pituitary axis disorder (stress, exercise, anorexia), Pituitary tumour (prolactinoma), Medication (OCP), Autoimmune (coeliac, pernicious anemia, thyroid), PCOS
Causes of Primary Amenorrhoea
Hypothyroidism
Turner’s Syndrome (45 XO)
Kallmann’s syndrome (normal stature + loss of smell)
True gonadal dysgenesis
Hepaphroditism
Androgen secreting tumour
Congenital Adrenal Hyperplasia
Androgen Insensitivity syndrome
Mullerian developmental abnormalities.
How do you manage a Pt with BP >160/100
> 45 YO Non idigenous
> 35 YO Indigenous
- Assess for known CV disease or CVD Risk if no known disease
- Frequent and sustained lifestyle advice and support (eg smoking cessation)
- If known CVD or Moderate (10-15%) to High Risk (+ 15%) consider commencing BP Lowering (eg. perindopril 5mg) and Lipid lowering (Atorvastatin 40mg) medication.
- Monitor individual risk factor response to interventions
- Regular review of absolute risk
Low risk = 2 yearly
Moderate RIsk = 6 - 12 monthly
High Risk = as clinically needed
4 Blood Pressure Lowering Combinations to Avoid:
- ACEI or ARB + K sparing diuretic (eg spironolactone) - May cause hyperkalemia
- Beta blocker + Verapamil or Diltiazem (CCB) - May cause heart block
- ACEI + ARB - May cause hypotension and kidney injury
- Betablocker + Thiazide diuretic - May potentiate worsening glycaemic control
Ideal BP medication combinations for the following:
- Diabetes
- Post MI
- CCF
- CAD
- Diabetes: ACEI (eg perindopril) + CCB (eg Amlodipine)
- Post MI: ACEI or ARB + Beta blocker (Atenolol 50mg BD)
- CCF: Thiazide Diuretic + ACEI or ARB
- CAD: Beta blocker + Dihydropyridine CCB (eg Amlodipine)
Absolute contraindications to Beta Blockers
Asthma
Moderate to Severe COPD
Decompensated Heart Failure
Cardiogenic Shock
2nd or 3rd degree Heart Block
Symptomatic Bradycardia
Severe Peripheral Vascular Disease
Sick Sinus Syndrome
Factors affecting adherance to medication
Education
Treatment Complexity
Doctor - Patient Relationship
Beliefs
Health literacy
Side effects.
Ecconomic factors (eg cost)
Dx and Treatment
Female
Lower abdominal pain and tenderness
Cervical motion tenderness
Adnexal tenderness
Temp + 38oC
Pevic Inflammatory Disease
14 Days Metronidazole 400mg TDS PO
14 Days Doxycycline (not preg) 100mg BD TDS
500mg Ceftriaxone IM stat
1 gm Azithromycin PO stat
Red Flags for Breast Lumps
Hard and Irregular
Skin dimpling or puckering
Skin oedema (peau d’orange)
Nipple discharge
Nipple distortion
Nipple eczema (Paget disease)
Probable Diagnosis of different types of nipple discharge:
- Bloodstained
- Green -Grey
- Yellow serous
- Yellow pus
- Milky white
- Bloodstained: Intraduct papilloma
- Green - Grey: Fibrocystic disease or duct ectasia
- Yellow serous: Intraducta carcinoma
- Yellow pus: Breast abscess
- Milky white: Galactorrhoea eg. hyperprolactinemia.
Differential Diagnosis for post coital bleeding
Cervical Ca
Intra-Uterine Ca
Chlamydia (< 30 YO)
Cervical ectropion
Cervical polyps
IUD
OCP (can change to higher oestrogen dose)
Ix:
Pap smear (all ages) if not last taken within 3/12
Referral for endometrial sampling (>35 yo)
Management of cycle irregularity
Under 35:
Reassurance, OCP
Over 35: Referred to Gynaecologist for consideration of hysteroscopy and endometrial sampling.
3 Most common bacterial causes of Otitis Media
Strep pneumoniae
Haemophilus influenzae
Moraxella catarrhalis
Considerations for commencing HRT
- Previous Breast Ca
- Presence of Distressing vasomotor symptoms
- Assess Cardiovascular Disease Risk (Known Cardiovascular Disease, Smoking, Lipids, BP)
- Oestrogen + Progesterone if Uterus still intact
- Lowest dose for shortest duration possible.
- OCP or IUD + Oestrogen if requiring contraception