general

Question 1

what does LD50 mean

Answer 1

Dose at which 50% of population found Lethal (keep below this dose)

Question 2

What does ED50 mean?

Answer 2

Dose at which 50% of population found drug to be effective (therapeutic intended dose)

Question 3

What is a Therapeutic Index aka margin of safety

Answer 3

difference between LD and ED50

Question 4

a little margin for dosing means….

Answer 4

a low therapeutic index
easier to overdose

Question 5

large margin for dosing

Answer 5

high therapeutic index
difficult to cause harm

Question 6

drug potency

Answer 6

ability for drug to take effect (how much is needed for intended treatment)

Question 7

drug toxicity

Answer 7

potential to do irreversible harm to bodily functions

Question 8

drug effect is modulated by…

Answer 8

absorption, distribution, metabolism, excretion

Question 9

what are agonists

Answer 9

keys that unlock receptors
- act like the neurotransmitters
- affinity AND efficacy

Question 10

antagonists

Answer 10

fit the lock but don’t open the door, compete with neurotransmitters and stop them from opening door (causing effect) - affinity not efficacy

Question 11

affinity is

Answer 11

the attraction that a drug has for a receptor site (how well it will bind)

Question 12

efficacy is..

Answer 12

the ability for a drug to induce a response once bound to the receptor site

Question 13

the effect of one drug (or NT) is minimised or abolished by another

Answer 13

Antagonism