General Flashcards
Silver sulfadiazine
Not ok with a sulfa allergy poor wound penetration No pseudomonas coverage Covers candida SE: granulocytopenia
Mafenide acetate
ie: sulfamylon OK with sulfa allergy Good for cartilage Good for pseudomonas SE: metabolic acidosis (inhibits carbonic anhydrase)
Silver nitrate
SE: methemoglobinemia (rare), hyponatremia
Tissue resistance
Greater resistance = increased heat energy
bone>fat>tendon>skin>muscle
>vessel>nerve
white phosphorus burn
Tx: water irrigation, Woods lamp, dermabrasion
Assoc with decreased Ca, increased Phos, sudden death
Hydrofluoric acid burn
Tx: calcium gluconate
High risk features of BCC
poorly defined borders recurrent lesion immunosuppressed patient site of prior XRT perineural involvement histologic subtype--morpheaform, basosquamous, sclerosing, mixed, micronodular
treatment of extensive, diffuse microcytic lymphatic malformation
sirolimus
especially useful for Kasabach Merritt
Gabapentin MOA
analogue of GABA
binds voltage-gated Ca channels to decrease release of excitatory neurotransmitters
Lidocaine MOA
acts on voltage-gated sodium channels to inhibit neuronal depolarization
First line tx mod to severe HS?
adalimumab (humira) or inflixumab (remicade)
anti-TNF agents
healing mechanism of vascularized bone grafts
osteogenesis
osteoconduction
creeping substitution
material acts as scaffold (cortical bone grafts, demineralized bone matrix)
osteoinduction
direct stimulation of mesenchymal cells at recipient site to differentiate into osteoprogenitor cells
ie. BMP, cancellous bone grafts
endochondral ossification
cartilaginous soft callus covering fracture is converted to bone
