Genentech

Question 1

Evrysdi (Risdiplam)

Answer 1

This is a drug that treats Spinal Muscular Atrophy. Polivy is an anti-79b drug antibody conjugate.

Question 2

Polivy plus R-CHP

Answer 2

This is a drug for treatment of diffuse large B cell lymphoma.

Question 3

Vabysmo (Faricimab)

Answer 3

This is a FDA approved bi specific antibody targeting VEGFA and Ang2. By inhibiting VEGFA, endothelial proliferation, neovascularization and vascular permeability is suppressed.

Question 4

Susvimo (Ranibizumab)

Answer 4

This is a FDA approved drug for wet or neovascular age related macular degeneration (a condition that can lead to severe loss of vision). The drug binds to VEGFA and prevents it from binding to VEGFR1 and VEGFR2 receptors on the surface of endothelial cells. Thus there is prevention of endothelial cell proliferation, vascular leakage and formation of new blood vessels.

Question 5

Angiopoietin 2

Answer 5

This is an antagonist for ANGPT1 and TIE2 expressed only at the sites of vascular remodelling.

Question 6

Emicizumab (Hemlibra)

Answer 6

This is a bi specific antibody used for treatment of haemophilia A.

Question 7

CONSONANCE Trial

Answer 7

This is a trial to assess the effects of the drug Ocrevus (Ocrelizumab) on Secondary and Primary Progressive Multiple Sclerosis.

Question 8

Symbol Digits Modalities Test

Answer 8

This is a test to assess a participant’s psychomotor speed which measures processing speed and motor speed.

Question 9

CITYSCAPE Trial (Tiragolumab + Atezolezumab)

Answer 9

This combination is not FDA approved yet but its effect on non small cell lung cancer is being evaluated. Better Objective Response and PFS reported compared with placebo in this randomized phase II trial.

Question 10

SKYSCRAPER-01 Trial

Answer 10

This is a phase III trial looking at tirogolumab and atezolizumab vs atezolizumab as an initial first line treatment for high PD-L1 high or locally advanced non small cell lung cancer.

Question 11

Herceptin

Answer 11

This is a drug for early and late stage metastatic breast cancer

Question 12

Rituxan

Answer 12

This is a CD20 monoclonal antibody used for treating certain forms of autoimmune diseases and cancer.

Question 13

Avastin

Answer 13

A drug under investigation for breast cancer

Question 14

Activase

Answer 14

This is a drug that was originally used for cardiovascular diseases but can also used for treatment of stroke.

Question 15

TNKase

Answer 15

This is a drug used for treatment of stroke and acts in 5 seconds.

Question 16

Tecentriq

Answer 16

This is a monoclonal antibody for program death receptor 1 (PD-1) or program death receptor ligand 1 (PD-L1)., removing inhibition of the immune response.