Amgen

Question 1

Aimovig

Answer 1

This is a drug developed by Amgen that treats migraines.

Question 2

Repatha

Answer 2

This is a drug made in Amgen that lowers LDL levels in people with high LDL levels. Repatha does this by targeting the protein PCSK9. PCSK9 binds to LDL receptors and prevents them from cycling back to the cell surface. Repatha by binding to PCSK9 inhibits its function and causes LDL receptor to cycle back to the cell surface. Hence LDL in the blood can be lowered.

Question 3

Enbrel

Answer 3

This is a drug that treats rheumatoid arthritis. It does so by binding to the cytokine TNF alpha, thus inhibiting its function.

Question 4

Lumakras (Sotorasib)

Answer 4

This is a drug that treats non small cell lung cancer that is caused by a mutation in the KRAS protein.

Question 5

Tezspire (Tezepelumab)

Answer 5

This is a drug developed at Amgen for people with severe asthma.

Question 6

Otezla (Apremilast)

Answer 6

This is FDA approved drug for plaque psoriasis. Mechanism of action is by inhibition of PDE4, increasing some anti-inflammatory cytokines and decreasing some pro-inflammatory cytokines.

Question 7

Epogen

Answer 7

This is a drug to treat anemia for patients with chronic kidney disease.

Question 8

BLINCYTO (Blinatumomab)

Answer 8

This is a FDA approved bi specific antibody used to treat Relapsed Refractory ALL.

Question 9

Riabni

Answer 9

This Is a FDA approved drug biosimilar to Rituxan for patients with moderate to severe rheumatoid arthritis.

Question 10

AMG673

Answer 10

This is a new CD33 x and CD3 BiTe antibody construct.

Question 11

Olpasiran

Answer 11

This is a siRNA that prevents assembly of Lp (a) By preventing translation of the apo (a) protein in the hepatocyte.