gene expression and human disease Flashcards
1
Q
What is Fragile-X syndrome caused by?
A
- expansion of CGG results in methylation of DNA in promotor
- prevents RNA polymerase complex assembling properly
2
Q
What are some symptoms of Fragile-X syndrome?
A
- large, protruding ears
- learning difficulties
- macro-orchidism
- double-jointed thumbs
- hyperextensible finger joints
3
Q
What are the 3 types of RNA polymerase?
A
RNA polymerase I, II, III
4
Q
Which genes does RNA polymerase I transcribe?
A
most rRNA genes
5
Q
Which genes does RNA polymerase II transcribe?
A
- protein-coding genes
- miRNA genes
- genes for some small RNAs
6
Q
Which genes does RNA polymerase III transcribe?
A
- tRNA genes
- 5S rRNA genes
- many small RNAs
7
Q
A
