gen pharm Flashcards
FDA requires that generics not be significantly different from the parent compounds in what way? (6x)
BIOEQUIVALENCE
After OD, pt has fever, confusion, tachycardia, dry mouth, urinary retention, dilated and unresponsive pupils. Which medication would treat this? (Anticholinergic toxicity) (4x)
PHYSOSTIGMINE
Pt presents to ED c/o ringing in ears, abdominal pain, and is found to have mild metabolic acidosis. Overdose of what substance? (4x)
ASPIRIN
Hepatitis C treatment with interferon can cause what psychiatric symptom? (3x)
DEPRESSION
Which of the following agents used to treat patients with Alzheimers disease has a mechanism of action related to an antiglutaminergic mechanism? (x2)
MEMANTINE
In addition to life support, which class of meds to consider for the treatment of neuroleptic malignant syndrome? (2x)
DOPAMINE AGONISTS (bromocriptine)
What medication may cause mood d/o in pts being treated for melanoma? Also worsens fatigue and cognitive inefficiency: (2x)
INTERFERON
What med is effective in tx of motor/vocal tics associated w Tourette syndrome refractory to tx with antipsychotics and alpha adrenergic agonists? (x2)
TETRABENAZINE
Pt confused, disoriented, dry mouth, dilated unresponsive pupils. Likely ingested: (2x)
BENZTROPINE
Flumazenil is used to treat: (2x)
BENZO INTOXICATION
This is a relative contraindication for interferon treatment in pt’s with Hepatitis C: (2x)
DEPRESSION WITH SUICIDAL IDEATION
The effects of caffeine on which of the following results in increased dopaminergic activity? (x2)
ADENOSINE RECEPTOR
A pt with cancer, pain, depressed mood, poor appetite, fatigue, impaired concentration, prognosis is less than three weeks. What should you treat with?
METHYLPHENIDATE
Contraindication for treatment for psychostimulants
UNDERLYING HEART DEFECT
54 yo female takes prozac 60 mg for MDD, having worsening migraines then fever, diarrhea, and “muscles are tightening up”. Which medicine is causing these sx?
SUMATRIPTAN
84 yo pt goes to ED with fever, dry mouth, visual hallucinations. Is found tachycardia, restless, toxicity of what medication most likely caused symptoms?
BENZTROPINE
Prolonged ingestion of high doses pyridoxine causes:
SUBACUTE SENSORY NEUROPATHY
Physostigmine is useful in treating toxic syndrome from overdose with:
SCOPOLAMINE
Pt in ED for treatment of OD - was found 4 hrs ago after ingesting 10 cold med packs of 650mg Tylenol, antihistamine, and alpha 1 agonist decongestant. Pt is pale and vomiting. How do you decide whether to use N-acetylcysteine as an antidote?
PT’S SERUM N-ACETYL-P-AMINOPHENOL (APAP) LEVEL OVER TIME
Tx of pts w/ substance abuse who have acute pain
PATIENT-CONTROLLED ANALGESIA
Which of the following agents has been shown to moderate weight gain in some pts treated w/ valproate and atypical antipsychotic?
METFORMIN
Pt took 20 tabs 500mg acetaminophen tabs 6 hours ago. Pt is 52kg, pulse 96, BP 135/65. Pt alert and in NAD. Serum acetaminophen level is 60 Ug/ml. Liver fxn test are minimally elevated. Most appropriate action?
N-ACETYL-CYSTEINE
A post-op pt’s was receiving 75mg IM meperidine. After switching to meperidine 100mg po pt reports inadequate pain relief. She has no past psych and abuse issues. This is due to:
THE LOWER POTENCY OF PO MEPERIDINE COMPARED TO IM
Acetylcysteine is Tx of choice for OD of:
ACETAMINOPHEN
OD on sleeping pill. Hot skin, blurry vision, urinary retention, dry mucous membranes, tachycardia, decreased bowel sounds. What is the pill?
DIPHENHYDRAMINE
Risk of hepatotoxicity will peak in how many hours after acetaminophen overdose?
72 TO 96 HOURS
MC complication of corticosteroid therapy?
MOOD DISORDER
Molecular targets for improving cognition in schizophrenia have shown promise via which of the following mechanisms?
D1 RECEPTOR AGONISM
Which med is helpful in Tourette Syndrome who can’t tolerate clonidine?
GUANFACINE
Guanfacine’s primary effect is through what mechanism of action?
PRESYNAPTIC ALPHA2 ADRENERGIC RECEPTOR ACTIVATION
Key element in emergency treatment of pt w serotonin syndrome, beyond stopping offending agent is:
SUPPORTING VITAL FUNCTIONS