anxiolytic

Question 1

What psychotropic can cause a decrease in benzo plasma levels? (6x)

Answer 1

CARBAMAZEPINE

Question 2

Which benzo accumulates with repeated administration, should be avoided in chronic renal failure, and most likely to accumulate with repeated dosing? (3x)

Answer 2

DIAZEPAM

Question 3

Which of the following medications would be preferable for use in an anxious patient with pulmonary disease? (3x)

Answer 3

BUSPIRONE

Question 4

If prescription benzo is necessary for a patient w/ severe hepatic dysfunction which of the following is most appropriate choice to avoid elevated serum levels. (2x)

Answer 4

LORAZEPAM

Question 5

Which benzo is reliably absorbed given IM? (2x)

Answer 5

LORAZEPAM

Question 6

Which of the following reverses the effects of benzodiazepines? (2X)

Answer 6

FLUMAZENIL

Question 7

47 yo with well controlled epilepsy well controlled on monotherapy develops nausea, ataxia, and diplopia when treated with erythromycin. Which antiepileptic?

Answer 7

CARBAMAZEPINE

Question 8

Decreases congenital malformations in women taking anti-epileptic medications

Answer 8

FOLIC ACID

Question 9

The use of flumazenil for treating benzo OD is limited by

Answer 9

THE RISK OF INDUCING WITHDRAWAL SEIZURES IN BENZO- DEPENDENT PTS

Question 10

75 y/o pt with cirrhosis should be given which of the following meds:

Answer 10

TEMAZEPAM

Question 11

False positive urine toxicology screen for Benzodiazepines?

Answer 11

SERTRALINE

Question 12

Buspirone is thought to exert anxiolytic effects primarily due to its actions at which receptor?

Answer 12

5HT-1A

Question 13

Benzo half-life < 6 hrs

Answer 13

TRIAZOLAM

Question 14

Pharmacokinetic property most related to relative abuse potential of benzos

Answer 14

TIME TO ONSET OF ACTION

Question 15

Benzodiazepam absorbed PO or IM

Answer 15

LORAZEPAM

Question 16

Benzo w/o active metabolites

Answer 16

LORAZEPAM

Question 17

Longest half-life amongst alprazolam, flurazepam, lorazepam, temazepam and triazolam

Answer 17

FLURAZEPAM (DALMANE) USED FOR INSOMNIA

Question 18

Most common side effect of benzos

Answer 18

DROWSINESS

Question 19

Which of the following benzos has an active metabolite?

Answer 19

CHLORDIAZEPOXIDE

Question 20

Which of the following sleep changes is produced by all benzos?

Answer 20

DECREASE IN REM

Question 21

Breakthrough panic anxiety in a patient treated with short-acting benzodiazepines can be managed by switching the pt to what medication?

Answer 21

CLONAZEPAM

Question 22

75 y/o pt has developed tolerance to clonazepam over many years, now taking 5mg clonazepam at night but still with poor sleep. Pt denies any mood or anxiety symptoms, no drug problems. Next step:

Answer 22

SLOWLY WITHDRAW THE PT’S CLONAZEPAM AND REEVALUATE

Question 23

Pts on chronic benzos develop:

Answer 23

AMNESIA

Question 24

Benzo that would be the safest to prescribe for a 70y/o pt:

Answer 24

LORAZEPAM

Question 25

35 yo patient presents with frequent panic attacks, which begin with feelings of dread, sweating, shaking, fear of doom and death lasting 20 min. Which medication provides immediate relief:

Answer 25

LORAZEPAM

Question 26

How likely is escalation of benzodiazepine dose when prescribed for long term use?

Answer 26

MOST PATIENTS WILL MAINTAIN A STABLE DOSE OVER TIME