anxiolytic Flashcards
What psychotropic can cause a decrease in benzo plasma levels? (6x)
CARBAMAZEPINE
Which benzo accumulates with repeated administration, should be avoided in chronic renal failure, and most likely to accumulate with repeated dosing? (3x)
DIAZEPAM
Which of the following medications would be preferable for use in an anxious patient with pulmonary disease? (3x)
BUSPIRONE
If prescription benzo is necessary for a patient w/ severe hepatic dysfunction which of the following is most appropriate choice to avoid elevated serum levels. (2x)
LORAZEPAM
Which benzo is reliably absorbed given IM? (2x)
LORAZEPAM
Which of the following reverses the effects of benzodiazepines? (2X)
FLUMAZENIL
47 yo with well controlled epilepsy well controlled on monotherapy develops nausea, ataxia, and diplopia when treated with erythromycin. Which antiepileptic?
CARBAMAZEPINE
Decreases congenital malformations in women taking anti-epileptic medications
FOLIC ACID
The use of flumazenil for treating benzo OD is limited by
THE RISK OF INDUCING WITHDRAWAL SEIZURES IN BENZO- DEPENDENT PTS
75 y/o pt with cirrhosis should be given which of the following meds:
TEMAZEPAM
False positive urine toxicology screen for Benzodiazepines?
SERTRALINE
Buspirone is thought to exert anxiolytic effects primarily due to its actions at which receptor?
5HT-1A
Benzo half-life < 6 hrs
TRIAZOLAM
Pharmacokinetic property most related to relative abuse potential of benzos
TIME TO ONSET OF ACTION
Benzodiazepam absorbed PO or IM
LORAZEPAM
Benzo w/o active metabolites
LORAZEPAM
Longest half-life amongst alprazolam, flurazepam, lorazepam, temazepam and triazolam
FLURAZEPAM (DALMANE) USED FOR INSOMNIA
Most common side effect of benzos
DROWSINESS
Which of the following benzos has an active metabolite?
CHLORDIAZEPOXIDE
Which of the following sleep changes is produced by all benzos?
DECREASE IN REM
Breakthrough panic anxiety in a patient treated with short-acting benzodiazepines can be managed by switching the pt to what medication?
CLONAZEPAM
75 y/o pt has developed tolerance to clonazepam over many years, now taking 5mg clonazepam at night but still with poor sleep. Pt denies any mood or anxiety symptoms, no drug problems. Next step:
SLOWLY WITHDRAW THE PT’S CLONAZEPAM AND REEVALUATE
Pts on chronic benzos develop:
AMNESIA
Benzo that would be the safest to prescribe for a 70y/o pt:
LORAZEPAM
35 yo patient presents with frequent panic attacks, which begin with feelings of dread, sweating, shaking, fear of doom and death lasting 20 min. Which medication provides immediate relief:
LORAZEPAM
How likely is escalation of benzodiazepine dose when prescribed for long term use?
MOST PATIENTS WILL MAINTAIN A STABLE DOSE OVER TIME
