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Farmaceutisch > Gecontroleerde Vrijstelling > Flashcards

Gecontroleerde Vrijstelling Flashcards

1
Q

Redenen

A

Verminderde inname frequentie
Werking snachts
Piekvonc vermijden

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2
Q

Manieren werking verlengen

A

Mod biologisch systeem (cyp inh)
Mod farmacon (slechter opl)
Mod toediening (dis, different, osmo druk, ion<->, muco-adhesie

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3
Q

Dissolutie systemen tekening

A

Reservoir en matrix

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4
Q

Diffusie systemen tekening

A

Reservoir en matrix

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5
Q

Osmotische systemen tekening

A

Semi permeabel membraan
Water in
Oplossen
Stroomt buiten

Dubbel en zonder opening

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6
Q

Ionen uitwisselaars

A

<-> farmacon en kationen maag darm
Niet eerste keus, afhankelijk veel fac

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7
Q

Muco adhesie +nadelen

A

Verblijftijd GI verlengen
Polymeren mucuslaag maag

Turn over, loskomen d’r mobiliteit, gebrek mechanische kracht voor adhesie

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8
Q

Parenterale gecontroleerde vrijstelling

A

Macro-kristallijne suspensie
Complex vorming polymeren
Esterificatie
Absorptie
Encapsulatie
Slecht oplosbare zouten

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Farmaceutisch (19 decks)

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