GBS Flashcards
Most common cause of rapidly-evolving motor paresis, paralysis, & sensory deficits
GBS
Maximal weakness in GBS reached in ___
2-3 weeks
Most common form of GBS
acute inflammatory demyelinating polyradiculopathy (AIDP)
Peak frequency = young adults, 5th-8th decades
Annual Incidence = 1-2/100,000
GBS
s/s: rapidly ascending symmetric motor weakness & distal sensory impairment
*progressive weakness in >1 extremity
GBS
Are DTR’s present in GBS?
No
1st neurological symptom in GBS?
parenthesis in the toes
How many cases of GBS require mechanical ventilation?
up to 30%
Palatal/facial involvement occurs in what % of cases of GBS?
50%
Variant of GBS characterized by cranial nn involvement & ataxia
Miller-Fisher Syndrome
Predictive factors of respiratory failure in GBS:
- time of onset to admission < 7 days
- inability to cough and/or stand
- inability to lift head and/or elbows
- increased liver enzymes
What is Muscle Belly Tenderness (MBT)?
bilateral tenderness to manual pressure in >=2 LE muscles > 1 week
- associated with longer LOS
What are predictors of poorer outcome for GBS (3)?
- Need for mechanical ventilation
- Onset of older age
- Significantly decreased evoked motor potential amplitude
What % with GBS have cranial nn involvement?
50%
What % with GBS have autonomic nervous system symptoms?
50% - orthostasis, urinary problems, sexual difficulties, sweating abnormalities, sluggish pupillary reaction, exercise intolerance
What % with GBS have MINOR remaining neurological deficits?
50% - diminished/absent DTRs
Most common long-term deficits of GBS
Tibialis anterior weakness
What % with GBS are ambulatory within 6 months of initial onset?
80%
IPR length of stay roughly doubles when patients have: (3)
- Axonal damage
- MBT
- ventilator dependence
What % report acute infection within 2 months preceding onset? (GBS)
67% (90% of these had illness preceding 30 days - GI, resp)
