GBS Flashcards
Rapid onset
Bilateral
Ascending weakness
Most common infectious cause, and other causes
Campylobacter
Is GBS UMN or LMN
LMN problem
Hyporeflexia
Reduced power
Reduced tone
What key investigation do you need to do?
Spirometry - lung function tests
Anterior horn cell pathology
Polio
ALMS
West nile virus
NMJ
Myasthenia gravis - anti-acetylcholine receptor
botulinum toxin - honey, tinned foods
Lambert- eaton syndrome
What is lambert eaton syndrome
improves with time
When do you get LES
Paraneoplastic syndrome - alongside small cell lung cancer
Myopathies
Voltage gated sodium channels
Management of
Steroids may delay recovery
Management of GBS
IVIG
How do you get GBS
Molecular mimicry of an infection
The lipopolysaccharide in bacteria can mimic the antigen structure of myelin, however not everyone gets it as everyone mounts a different antibody to the bacteria