GBS

Answer 1

Rapid onset
Bilateral
Ascending weakness

Question 2

Most common infectious cause, and other causes

Answer 2

Campylobacter

Question 3

Is GBS UMN or LMN

Answer 3

LMN problem

Hyporeflexia
Reduced power
Reduced tone

Question 4

What key investigation do you need to do?

Answer 4

Spirometry - lung function tests

Question 5

Anterior horn cell pathology

Answer 5

Polio
ALMS
West nile virus

Question 6

NMJ

Answer 6

Myasthenia gravis - anti-acetylcholine receptor
botulinum toxin - honey, tinned foods
Lambert- eaton syndrome

Question 7

What is lambert eaton syndrome

Answer 7

improves with time

Question 8

When do you get LES

Answer 8

Paraneoplastic syndrome - alongside small cell lung cancer

Question 9

Myopathies

Answer 10

Voltage gated sodium channels

Question 11

Management of

Answer 11

Steroids may delay recovery

Question 12

Management of GBS

Answer 12

IVIG

Question 13

How do you get GBS

Answer 13

Molecular mimicry of an infection

The lipopolysaccharide in bacteria can mimic the antigen structure of myelin, however not everyone gets it as everyone mounts a different antibody to the bacteria