GastrointestinalReview Flashcards

1
Q

How is Barrett’s esophagus defined? What types of cells are replaced with other types (metaplasia)?

A

A premalignant condition, where the esophageal squamous epithelium is replaced by intestinal epithelium. This intestinal epithelium, also called specialized intestinal metaplasia (SIM) (with caliciform cells) forms the essence of the concept of Barrett’s esophagus.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

When is Barrett’s typically found? Ages associated with it? More common in men or women?

A

During an upper endoscopy, in individuals that are middle-aged or older. Mean age of diagnosis has been reported at age 55. 2-3 times more common in men.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

According to the ACG, recommendations for frequency of screening for Barrett’s in men vs. women?

A

Screen only in men with weekly GERD symptoms or symptoms
>5years, with 2 or more known risk factors. Routine screening in women is not recommended unless multiple risk
factors exist and pt. has a documented family hx (first-degree
relative) of Barrett’s or esophageal adenocarcinoma.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Most cases of Barrett’s involve how much of the esophagus? How much length to be long-segment type?

A

A short-segment of the esophagus (<3 cm). Long-segment Barrett’s (where the metaplastic segment is 3 cm or more) is uncommon in patients not reporting heartburn symptoms.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Long-segment vs short-segment Barrett’s prevalence?

A

In 3-5% of pts. reporting chronic GERD symptoms, long-segment has been reported. In 10-15%, short-segment is reported. Prevalence of intestinal metaplasia has been reported to be 13.2% with long-segment reported at 1.6%, short-segment at 6.4%, and the GEJ at 5.6%.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly