Gastrointestinal conditions 3 Flashcards

Final part of GI conditions

1
Q

What is Peptic ulcer disease?

A

A break in the mucosal lining of the stomach or duodenum more than 5mm in diameter, with depth to submucosa

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2
Q

What causes Peptic ulcer disease?

A

Imbalance between the damaging action of acid and pepsin and protective mechanisms
2 major aetological factors - H. Pylori or NSAID overuse
Most common causes: H. Pylori, NSAIDs, Alcohol, Bisphosphonates, Smoking
Rare causes: Zollinger-Ellison syndrome (Gastrin-secreting tumour)

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3
Q

What are the Risk Factors for Peptic ulcer disease?

A
Helicobacter Pylori infection
NSAID use
Smoking
Increasing age
Personal history
Family history
Patient in intensive care
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4
Q

What are the symptoms of Peptic ulcer disease?

A
Abdominal pain (Epigastric tenderness)
Nausea 
Vomiting
Weight loss
Anorexia
Diarrhoea
Anaemia
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5
Q

What are the signs of Peptic ulcer disease?

A

GI bleeding
Hypotensive or septic shock
Succussion splash

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6
Q

What are the investigations for Peptic ulcer disease?

A
if <55 and no red flags
- H pylori breath test/stool antigen test
- FBC
- Stool occult blood test
- Serum Gastrin
if >55 or red flags present
- Upper GI endoscopy + biopsy
- If ulcer present: Repeat endoscopy 6-8 weeks 
FBC 
Serum amylase
Clotting screen
LFT
Urea breath test for H. Pylori
Blood antibody test
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7
Q

How do you manage Peptic ulcer disease?

A
Acute:
Fluids/Resuscitation needed if ulcer is perforated or bleeding
Close monitoring of vital signs
Endoscopy
Surgical treatment
Endoscopy:
- If Ulcer is bleeding, haemostasis with: Injection sclerotherapy, laser coagulation, electrocoagulation
Surgery: if perforated
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8
Q

What are complications of peptic ulcer disease?

A

Perforation
Gastric outlet obstruction
Upper GI bleeding
Perforation

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9
Q

What is a Perianal abscess?

A

A pus collection in the perianal region

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10
Q

What is a perianal fistula?

A

An abnormal chronically infected tract communicating between the perineal skin and either the anal canal or the rectum

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11
Q

What causes perianal abscesses/fistulae?

A

Bacterial infection
Fistulae develops as a complication of an abscess
Fistulae can develop as a complication of Crohn’s disease

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12
Q

What are the Risk factors for perianal abscesses and fistulae?

A
IBD
Diabetes Mellitus
Malignancy
MSM (men who have sex with men)
Immunocompromised
Crohns/diverticular disease
20-60 years old
Male sex
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13
Q

What are the symptoms of Perianal abscesses and fistulae?

A
Painful, hardened tissue in the perianal area
Pus discharge from rectum
Lump or nodule
Tenderness at edge of anus
Fever
Constipation
Pain with bowel movements
Constant and throbbing pain while sat down
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14
Q

What are signs of perianal abscesses and fistulae?

A

Seen on rectal exam

Swollen, red, tender lumps at edge of anus

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15
Q

What investigations are done for perianal abscesses and fistulae?

A

DRE usually normal
STD screening
Proctosigmoidoscopy
performed to exclude associated diagnoses
Transperitoneal US may be a useful adjunct

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16
Q

How do you manage Perianal abscesses and fistulae?

A

Prompt drainage
Medication for pain relief
ABx not needed unless diabetic or immunosuppressed
Probe is inserted to explore fistulae
Dye inserted into external opening to allow you to find the internal opening
Low fistula - fistuloltomy
High fistula - seton

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17
Q

What are the complications of perianal abscesses and fistulae?

A

Recurrence
Damage to internal anal sphincter
Incontinence
Persisting pain

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18
Q

What is Peritonitis?

A

Inflammation of the peritoneal lining of the abdominal cavity. It can be localised to one part of the peritoneum or generalised

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19
Q

What are the types of Peritonitis?

A

Localised
Primary generalised
Secondary generalised
Primary

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20
Q

What causes localised peritonitis?

A

Appendicitis
Cholecystitis
DIverticulitis
Salpingitis

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21
Q

What causes Primary generalised peritonitis?

A

Bacterial infection of the peritoneal cavity without an obvious source

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22
Q

What causes Secondary generalised peritonitis?

A

Caused by bacterial translocation from a localised focus

Could be non-bacterial due to spillage of bowel contents, bile and blood

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23
Q

What are the risk factors for peritonitis?

A

Ascites

Nephrotic syndrome

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24
Q

What are the symptoms of Peritonitis?

A

Usually continuous, sharp, localised exacerbated by movement and coughing
May be vague in those with liver disease and ascites (due to confusion)

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25
What are the signs of peritonitis?
``` Check vitals and look for signs of dehydration or compromised perfusion Localised peritonitis (Tenderness on exam, Guarding, Rebound tenderness) Generalised peritonitis (Very unwell, Systemic signs of toxaemia, lie still, shallow breathing, rigid abdomen) ```
26
What blood tests are done for Peritonitis?
``` FBC LFT U&E Amylase Clotting Blood culture Pregnancy test ABG ```
27
What other tests are done for Peritonitis?
``` Erect CXR (Check for perforation) AXR (Obstruction) USS or CT abdomen Laparoscopy If ascites - ascitic tap ```
28
How do you manage localised peritonitis?
Depends on cause | Some may need surgery and some are treated with antibiotics
29
How do you manage generalised peritonitis?
``` Risk of death from sepsis or shock IV Fluids IV Abx Urinary catheter NG tube Central venous line Laparotomy Primary peritonitis ```
30
How do you treat SBP?
Quinolone antibiotics - OR - Cefuroxime + Metronidazole
31
What are the complications of Peritonitis?
``` Early - Septic shock - Respiratory failure - Multiorgan failure - Paralytic ileus - Wound infection - Abscesses Late - Incisional hernia - Adhesions ```
32
What is a pilonidal sinus?
Forceful insertion of hairs into the skin of the natal cleft in the sacrococcygeal area. This promotes a chronic inflammatory reaction, causing an epithilialised sinus.
33
What causes a pilonidal sinus?
Hair in the natal cleft More common in hairy people Ingrowing of hairs excites a foreign body inflammatory reaction and may cause secondary tracks to open laterally +/- abscesses with foul-smelling discharge
34
What are Risk Factors for Pilonidal sinus?
``` Male 16-40 Family history Stiff hair Hirsutism ```
35
What are symptoms of Pilonidal sinus?
Painful natal cleft Discharging swelling Often recurrent
36
What are the signs of pilonidal sinus?
Midline openings or pits between the buttocks Hairs may protrude from the swelling If infection or abscess, swelling will become tender May be fluctuant and discharge pus or blood-stained fluid on compression
37
What are the investigations for Pilonidal Sinus?
None needed Bloods (Sign of infection) - Leucocytosis - Fasting glucose (Diabetics at risk)
38
What is the management of Pilonidal sinus?
Pre-op antibiotics Acute pilonidal abscess (incision and drainage) Chronic pilonidal sinus (Excision under GA with exploration) Prevention (Good hygiene and shaving)
39
What are the complications of Pilonidal sinus?
Pain Infection Abscess Recurrence
40
What is Portal Hypertension?
Abnormally high pressure within the hepatic portal vein | - Hepatic venous pressure >10mmHg
41
What causes portal hypertension?
Cirrhosis is the most common cause Collagen deposition and fibrosis Sodium retention and vasoactive substances such as NO 3 categories: Pre-Hepatic Hepaitc Post-Hepatic
42
What are pre-hepatic causes of portal hypertension?
Blockage of portal vein before the liver - Congenital stenosis - Portal vein thrombosis - Splenic vein thrombosis - Extrinsic compression
43
What are hepatic causes of portal hypertension?
``` Cirrhosis Chronic hepatitis Schistosomiasis Granulomata Myeloproliferative disorder ```
44
What are post-hepatic causes of portal hypertension?
Blockage of hepatic veins or venules - Budd-Chiari syndrome - Constrictive pericarditis - Right Heart failure
45
What are the Risk Factors for Portal hypertension? (Same as cirrhosis)
``` Alcoholic liver disease Hepatitis C/B Continued alcohol consumption increases rate of progression of cirrhosis from any cause Male Older age Hypertension Hyperlipidaemia ```
46
What are the symptoms of Portal hypertension?
``` Jaundice History of alcohol abuse Risk for Viral hepatitis Family history (e.g. Haemochromatosis) Haematemesis/melaena Lethargy, irritability, chenges in sleep Abdominal distention Abdominal pain and fever Pulmonary involvement ```
47
What are the signs of portal hypertension?
``` Caput medusae Splenomegaly Ascites Jaundice Spider naevi Palmar erythema Gynaecomastia Testicular atrophy ```
48
What investigations are done for Portal Hypertension?
``` LFTs U&Es Blood glucose FBC Clotting screen (Prolongation of PT in liver failure) Ferriting Hepatitis serology Autoantibodies (ASMA in AI hep) Alpha1-antitrypsin Ceruloplasmin Abdominal sultrasound Doppler ultrasound Hepatic venous pressure ```
49
How do you manage Portal hypertension?
Telipressin and prophylactic antibiotic Endoscopy in 12hrs, treat with Band ligation or Injection sclerotherapy IF not enough, TIPS Liver transplant most curative Beta blockers for prophylaxis of variceal bleed
50
What are the complications of Portal hypertension?
Bleeding from oesophageal varices Ascites + complications (SBP, Hepatorenal syndrome, hepatic hydrothorax) Pulmonary complications (Hepatopulmonary syndrome) Liver failure Hepatic encephalopathy Cirrhotic cardiomyopathy
51
What is the triad of Hepatopulmonary syndrome?
``` Hepatic dysfunction Hypoxaemia Extreme vasodilation (Intrapulmonary vascular dilatation) ```
52
What is Primary Billiary cirrhosis?
AI chronic inflammatory liver disease involving progressive destruction of intrahepatic bile ducts, leading to cholestasis, and ultimately, cirrhosis
53
What causes primary biliary cirrhosis?
AI disease Environmentally triggered in those predisposed High concordance in twins Strong Family histories Characterised by chronic AI granulomatous inflammation which leads to fibrosis, cirrhosis and portal HTN
54
What are the Risk Factors for Primary biliary cirrhosis?
Women 45-55 Northern European descent Family history
55
What are the symptoms of Primary Biliary cirrhosis?
Incidental finding (Raised ALP) Vague symptoms (Fatigue, weight loss, pruritus) Discomfort in RUQ Complication of liver decompensation May present with assocaited symptoms (e.g. Sjorgen's syndrome, arthritis, raynaud's phenomenom)
56
What are the Signs of Primary Biliary cirrhosis?
``` Early - no signs Late - Jaundice - Skin pigmentation - Scratch marks - Xanthomas - Hepatosplenomegaly - Ascites - Signs of chronic liver disease ```
57
What are the investigations for PBC?
LFT (High ALP + GGT, Raised bilirubin, Low albumin, High PT time) Clotting: Prolongation of PT Antimitochondrial antibodies (AMAs hallmark of PBC) High IgM High cholesterol TFTs US (Exclude gallstones)
58
What is Primary sclerosing cholangitis?
A chronic cholestatic liver disease chatacterised by progressive periductal or intrahepatic and extrahepatic bile ducts, leading to reactive proliferation and fibrosis, and eventually cirrhosis
59
What causes primary sclerosing cholangitis?
``` Periductal inflammation with peridcutal concentric fibrosis Portal oedema Bile duct proliferation Expansion of portal tracts Progressive fibrosis Development of biliary cirrhosis ```
60
What are the Risk factors for Primary sclerosing cholangitis?
Male IBD Genetic predisposition
61
What are the symptoms of Primary sclerosing cholangitis?
``` Asymptomatic, diagnosed after persistent ALP Present with: - Intermittent jaundice - Pruritis - RUQ pain - Weight loss - Fatigue ```
62
What are the signs of Primary sclerosing cholangitis?
``` No signs Jaundice Hepatosplenomegaly Spider naevi Palmar erythema Ascites ```
63
What are the investigations for Primary sclerosing cholangitis?
LFT (High ALP, mildly elevated ALT+ AST, low albumin + high bilirubin) Serology (IgG high in kids, IgM high in adults, ASMA and ANA in 30%, pANCA in 70%) ERCP - beaded appearance LIver biopsy (Fibrosis, obliterative cholangitis)
64
What is a Rectal prolapse?
Abnormal protrusion of the full thickness (Or only the mucosal layer) of rectum through the anus
65
What causes a rectal prolapse?
Straining Abnormal rectal anatomy or physiology (e.g. Pelvic floor weakness, poor fixation of rectum or reduced anal sphincter pressure)
66
What are the Risk Factors for rectal prolapse?
``` Constipation Cause of increased straining Cystic fibrosis (Children) Previous trauma to the anus/perineum Neurological conditions (e.g. Cauda equina syndrome, MS) ```
67
What are the symptoms of Rectal prolapse?
``` Protruding anal mass Initially with defecation May need digital replacement Constipation Faecal incontinence - in 75% PR mucous or bleeding Emergency! (Irreducible or strangulated) ```
68
What are the signs of Rectal prolapse?
Prolapse may be seen on straining May be ulcerated or necrotic if vascular supply is compromised Reduced anal sphincter tone
69
What investigations can be done for Rectal prolapse?
``` Proctosigmoidoscopy Defecating proctogram or barium enema Anal sphincter manometry Pudendal nerve studies Sweat chloride test (test for CF - >30) ```
70
What is Viral Hepatitis?
Viruses, formed of 6 different types | Other can infect liver include: CMV, EBV, yellow fever and Herpes
71
What are the 6 types of Viral hepatitis?
``` A B C D E G ```
72
Which of the Hepatitis' viruses are RNA viruses?
Hepatitis A and E
73
What is the incubation period for HAV/HEV?
3-6 weeks
74
What conditions do Picornavirus and Calicivirus cause?
Picornavirus - HAV | Calicivirus - HEV
75
What are the Risk Factors for Hepatitis A infection?
Living in endemic regions Close personal contact with an infected person MSM Known food-borne outbreak International travel Illicit drug use Contact with a child or employee in a childcare centre
76
How are HAV/HEV transmitted?
Faecal-oral route
77
What are the presenting symptoms of Hepatitis A/E?
``` Prodromal period - Malaise - Anorexia - Fever - Nausea and vomiting Hepatitis symptoms: - Dark Urine - Pale stools - Jaundice aroudn 3 weeks - Occasionally itching and jaundice last several weeks in HAV infection ```
78
What are the signs of Hepatitis A/E?
``` Pyrexia Jaundice Tender hepatomegaly Spleen may be palpable Absence of chronic liver disease (Some spider naevi appear transiently) ```
79
What investigations are done for Hep A/E?
``` LFTs (High AST, ALP, ALT and bilirubin) High ESR Low Albumin + High platelets Hep B and C serology Hep A - IgM (acute), IgG (recovery phase) Hep E - IgM (Raised), igG Urinalsysis (Bilirubin, urobilinogen) ```
80
What is the management of Hep A/E?
No specific management other than bed rest and symptomatic treatment Prevention and control (notifiable disease)
81
What are the complications of Hep A/E?
Fulminant hepatic failure Cholestatic hepatitis Post-hepatitis syndrome
82
What is the prognosis of someone with Hep A/E?
Recovery 3-6 weeks May relapse in recovery No chronic sequelae Fulminant hepatic failure has mortality of 80%
83
What is Hepatitis D?
A defective virus that may co-infect with HBV or superinfect people who already carry HBV
84
What type of virus is HBV?
Acute or chronic condition caused by a partial dsDNA virus
85
How is HBV transmitted?
Sexual contact Blood Vertical transmission
86
What type of virus is HDV?
ssRNA coated with HBsAg
87
What are the Risk Factors for HBV?
``` Living In endemic regions Close personal contact with an infected person MSM Known food-borne outbreak International travel Illicit drug use Contact with a child or employee in a childcare centre Infants of HBEAg/HBsAg ```
88
What are the symptoms of HBV?
``` Incubation period: 3-6 months 1-2 week prodrome - Malaise - Headache - Anorexia - Nausea and Vomiting - Diarrhoea - RUQ pain - Serum sickness type illness may develop Jaundice Recovery 4-8 weeks later Chronic carriage may be diagnosed after routine LFT testing ```
89
What are the acute signs of HBV?
``` Jaundice Pyrexia Tender hepatomegaly Splenomegaly Cervical lymphadenopathy Occasionally: Urticaria and Maculopapular rash ```
90
What are the chronic signs of HBV?
May be no findings | May have signs of chronic liver disease or decompensation
91
What investigations are done fro HBV?
Viral serology LFTs (High AST, ALT, ALP, bilirubin) High PT Liver Biopsy
92
What is seen on Viral serology for acute HBV infection?
HBsAg positive IgM anti-HBsAg negative +/- HBeAg
93
What is seen on Viral serology for chronic HBV infection?
HBsAg Positive IgG Anti-HBcAg +/- HBeAg (correlates with severity)
94
What is seen on Viral serology for HBV cleared?
Anti-HBsAg antibody positive | IgG anti-HBcAg
95
What is seen on Viral serology for HBV vaccinated?
HBsAg positive
96
What is seen on Viral serology for HDV infection?
Detested by IgM or IgG against HDV | PCR used to detect HDV
97
How do you manage HBV infections?
Prevention: Blood screening, safe sec, instrument sterilisation Passive immunisation Active immunisation Symptomatic treatment Indications for antiviral treatment (Interferon alpha > Nucleoside/nucleotide analogues)
98
What are indications for antiviral treatment?
HBeAg positive Or negative with signs of chronic hepatitis Compensated cirrhosis Decompensated cirrhosis
99
What is HCV?
A hepatitis C infection, often following a chronic course
100
What type of Virus is hepatitis C?
Ss-RNA
101
How is HCV transmitted?
Transmitted by percutaneous blood exposure | Sexual activity, perinatally, intranasal drug activity or accidental blood contact
102
What does liver biopsy show?
``` Chronic hepatitis IV or intranasal drug use Blood transfusion or organ transplant Birth between 1945 and 1965 Heavy alcohol use IL-28 gene polymorphism HIV Incarceration/institutionalism Haemodialysis Healthcare work Tattoos Multiple sex partners Infected mother Male sex ```
103
What are the symptoms of HCV
90% of infections are asymptomatic 10% become jaundiced with mild flu-like illness May be diagnosed after incidental abnormal LFT or in older patients with complications of cirrhosis
104
What are the signs of HCV?
No signs May be signs of chronic liver disease Extrahepatic manifestations (Skin rash, Renal dysfunction due to glomerulonephritis)
105
What are the investigations of HCV?
``` HCV serology (Anti HCV antibodies - IgM + IgG (acute), IgG (Chronic)) Reverse transcriptase PCR LFT (Acute: High ALT, AST and bilirubin Chronic: 2-8x AST+ALT) Liver Biopsy (Diagnose cirrhosis) ```
106
What is the management of HCV?
Prevention - Screen blood, blood products and organ donors - Needle exchange schemes for IV drug users - Instrument sterilisation - No vaccine available Medical - Acute (mainly supportive) - Chronic (Pegylated interferon alpha, Ribavirin) Duration: HCV 1/4 - 24-48 weeks; HCV 2/3 - 12-24 weeks
107
What are the complications of HCV?
Fulminant hepatic failure Chronic carriage of HCV Hepatocellular carcinoma Less common Prophyria cutanea tarda, cryoglobulinaemia, glomerulonephritis
108
What is Vitamin A deficiency?
A condition that causes Xerophthalmia (ocular manifestations)
109
What is the cause of Vitamin A deficiency?
Inadequate intake | Fat malabsorption
110
What is Xerophthalmia?
Dryness of conjunctiva and cornea of eye with inflammation and ridge formation
111
What are the Risk factors for Vitamin A deficiency?
Diet mainly consisting of rice
112
What are the signs and symptoms of vitamin A deficiency?
Night blindness progressing to complete blindness Dry/Dull/thick conjunctival xerosis and corneal xerosis Drying/Scaling of skin
113
What investigations are done for Vitamin deficiencies?
``` A:Eye tests and serum retinol binding protein B: Clinical diagnosis C: Clinical diagnosis D: Low calcium, phosphate, vit D and raised ALP LOoser's xones and osteopenia on CXR E: Clinical diagnosis K: Increased PT time ```
114
How do you manage vitamin deficiencies?
``` Supplements - in Vit. D treat underlying cause Vit A - supplements Vit B - Pabrinex Vit C (Ascorbic acid) Vit D (Treat underlying cause) Vit E / K (supplements) ```
115
What are the complications of Vitamin deficiencies?
``` A:Blindness and Respiratory infections B: Wernicke's encephalopathy C: Scurby D: Bone deformities and calcium deficiency E: Visual loss and weakness K: Anaemia ```
116
What is caused by Vitamin B1 deficiency?
Beri beri - leading to Wernicke's encephalopathy Can be: Dry - nervous system involvement Wet - Cardiovascular involvement
117
What is caused by Vitamin B2 (Riboflavin) deficiency?
Angular stomatitis, Cheilitis
118
What is caused by Vitamin B6 (pyridoxine) deficiency?
Polyneuropathy
119
What is caused by Vitamin C deficiency?
Scurvy
120
What is caused by vitamin D deficiency?
Rickets / Osteomalacia
121
What is caused by Vitamin E deficiency?
Haemolysis | Neurological deficit
122
What is caused by Vitamin K deficiency?
Bleeding disorders
123
Who are the vitamin deficiencies common in?
``` A: Southern/east asian people B: Alcoholics C: Pregnancies D: MEDC's and women E: Very rare K: Rare but not as rare in infants ```
124
What are the risk factors of general vitamin B deficiencies?
Increased tea/coffee/rice consumption | Alcoholism/Starvation/Vomiting/GI surgery
125
What are the Risk Factors for Vitamin C deficiency?
Pregnancy
126
What are the Risk Factors for Vitamin D deficiency?
Lack of sunlight CKD Vitamin D resistance
127
What are the Risk factors for vitamin E deficiency?
Cystic fibrosis/chronic cholestatic hepatobiliary diseae/short bowel syndrome Abetalipproteinaemia
128
What are the Risk factors for Vitamin K deficiency?
Anticoagulatns Antibiotics that interfere with Vit K absorption Infants with low Vit K breast milk
129
What are the symptoms and signs of Vitamin B deficiency?
``` B1 Dry: Numbness, confusion, difficulty moving legs, pain Wet: Palpitations, SOB, Oedema B2 Angular stomatitis B6 Polyneuropathy ```
130
What are the signs and symptoms of vitamin c deficiency?
``` Fatigues Weakness Cachexia Gingivitis Bleeding gums Halitosis petechiae/rash ```
131
What are the signs and symptoms of Vitamin D deficiency/
Rickets: Hypotonia, Short, bow legs and bossing of frontal/parietal bones Osteomalacia: Bone pain, weakness and malaise - can cause trousseauchvostek sign
132
What are the signs and symptoms of Vitamin E deficiency?
``` Weakness Hyporeflexia Ataxia Loss of vibrational sense Visual field decline ```
133
What are the signs and symptoms of Vitamin K deficiency?
Ecchymosis melaena Epistaxis
134
What occurs in people who are Calcium deficient?
``` CATs go Numb Confusion Arrhythima Tetany Numbness ```
135
What is tetany?
intermittent Muscular spasms caused by calcium deficiencies
136
What is Vitamin B12/Folate deficiency?
Having insufficient vitamin B12/Folate
137
What causes Vitamin B12 deficiency?
``` B12 found in meats and animal protein food Pernicious anaemia common cause Veganism Gastrectomy Drugs (Colchicine, metformin) ```
138
What causes folate deficiency?
Found in vegetables /fruit | Caused by: Decreased dietary intakes / decreased absorption
139
What are the Risk factors for B12 deficiency?
Low dietary intake Drugs: Metformin, H2 antagonism/PPI Malabsorption (Coeliac, crohns, IBD, surgery, disease)
140
What are the Risk Factors for Folate deficiency?
``` Low dietary intake Drugs: Trimethoprim, methotrexate, sulfasalazine Malabsorption (IBD, Coeliac, congenital) Alcoholism Pregnancy Prematurity ```
141
What are the symptoms of B12 deficiency?
``` Typical anaemia (Fatigue, lethargy, dyspnoea, faintness, palpiataions, headaches) Neurological symptoms ( paraesthesia, numbness, congnitive changes) ```
142
What are the symptoms of Folate deficiency?
Very few unless pregnant | General anaemia symptoms
143
What are the signs of Vitamin B12 deficiency?
Pallor Heart failure (severe anaemia) Glossitis Angular stomatitis Neuropsychiatric: Irritability, dementia, depression Neurological: Subacute combined degeneration of the spinal cord, peripheral neuropathy
144
What investigations are done for diagnosing Vitamin B12 deficiency?
``` Measure serum B12 Blood film (Hypersegmented neutrophils, Oval macrocytes, circulating megaloblasts) Pernicious anaemia tests (anti-intrinsic factor antibodies, anti-parietal cell antbodies, Schilling test - specific for B12) ```
145
What is a volvulus?
Malrotation of a loop of bowel around the axis of its mesentry that results in bowel obstruction and potential ischaemia
146
What are the types of volvulus?
Sigmoid (65%) Caecal (30%) Volvulus neonatum - in neonates typically affects midgut
147
What are the risk factors for a volvulus?
``` Malrotation - neonatal Enlarged colon Hirschprung disease Pregnancy Abdominal adhesions Chronic constipaiton Increased fibre diet ```
148
What are the symptoms of a volvulus?
``` Severe colicky abdominal pain and swelling Absolute constipation Vomiting May be history of TIAs Neonatal volvulus is aorund 3months ```
149
What are the signs of a volvulus?
``` Signs of bowel obstruction with distention and tenderness - Absent or tinkling bowel sounds fever tachycardia signs of dehydration ```
150
What investigations are done in volvulus?
Abdominal X-ray - Coffee bean sign (sigmoid) or embryonic sign (caecal) Erect CXR ( Check for perforation) Water-soluble contract enema CT scan
151
What is Wilson's disease?
An autosomal recessive disorder characterised by reduced biliary excretion of copper and accumulation of copper in the liver and brain, especially in the basal ganlis Also known as hepatolenticular degeneration
152
What causes wilson's disease?
Mutation in Chromosome 13 codes for ATP7B in hepatocytes Interferes with transport of copper into the intracellular compartments for incorporation into ceruloplasmin Excess copper damages hepatocyte mitchochondira, leading to cell death and release of copper This copper depostis in tissues and imparis funciton
153
What are the Hepatic symptoms of Wilson's disease?
``` Hepatitis, Liver failure, cirrhosis May also be: - Jaundice - Easy bruising - Variceal bleeding - Encephalopathy ```
154
What are the Neurological symptoms of wilson's disease?
``` Dyskinesia Rigidity Tremor Dystonia Dysarthria Dysphagia Drooling Dementia Ataxia ```
155
What are the Psychiatric symptoms of Wilson's disease?
Conduct disorder Personality change Psychosis
156
What are the signs of Wilson's disease?
``` Hepatosplenomegaly Jaundice Ascites/oedema Gynaecomastia Kayser-Fleisher rings (Slit lamp) Sunflower cataract (Slit lamp) ```
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What investigations are done for suspected wilson's disease?
LFTs (High AST, high ALT, High ALP) Serum caeruloplasmin (low) - is an acute phase protein so may give false negative Serum copper - raised 24hr copper levesl - increased LIver biopsy - copper content Genetic analysis - wilsons MRI - degeneration in basal ganglia, fronto-temporal, cerebellar, brainstem