Gastrointestinal conditions 3 Flashcards
Final part of GI conditions
What is Peptic ulcer disease?
A break in the mucosal lining of the stomach or duodenum more than 5mm in diameter, with depth to submucosa
What causes Peptic ulcer disease?
Imbalance between the damaging action of acid and pepsin and protective mechanisms
2 major aetological factors - H. Pylori or NSAID overuse
Most common causes: H. Pylori, NSAIDs, Alcohol, Bisphosphonates, Smoking
Rare causes: Zollinger-Ellison syndrome (Gastrin-secreting tumour)
What are the Risk Factors for Peptic ulcer disease?
Helicobacter Pylori infection NSAID use Smoking Increasing age Personal history Family history Patient in intensive care
What are the symptoms of Peptic ulcer disease?
Abdominal pain (Epigastric tenderness) Nausea Vomiting Weight loss Anorexia Diarrhoea Anaemia
What are the signs of Peptic ulcer disease?
GI bleeding
Hypotensive or septic shock
Succussion splash
What are the investigations for Peptic ulcer disease?
if <55 and no red flags - H pylori breath test/stool antigen test - FBC - Stool occult blood test - Serum Gastrin if >55 or red flags present - Upper GI endoscopy + biopsy - If ulcer present: Repeat endoscopy 6-8 weeks FBC Serum amylase Clotting screen LFT Urea breath test for H. Pylori Blood antibody test
How do you manage Peptic ulcer disease?
Acute: Fluids/Resuscitation needed if ulcer is perforated or bleeding Close monitoring of vital signs Endoscopy Surgical treatment Endoscopy: - If Ulcer is bleeding, haemostasis with: Injection sclerotherapy, laser coagulation, electrocoagulation Surgery: if perforated
What are complications of peptic ulcer disease?
Perforation
Gastric outlet obstruction
Upper GI bleeding
Perforation
What is a Perianal abscess?
A pus collection in the perianal region
What is a perianal fistula?
An abnormal chronically infected tract communicating between the perineal skin and either the anal canal or the rectum
What causes perianal abscesses/fistulae?
Bacterial infection
Fistulae develops as a complication of an abscess
Fistulae can develop as a complication of Crohn’s disease
What are the Risk factors for perianal abscesses and fistulae?
IBD Diabetes Mellitus Malignancy MSM (men who have sex with men) Immunocompromised Crohns/diverticular disease 20-60 years old Male sex
What are the symptoms of Perianal abscesses and fistulae?
Painful, hardened tissue in the perianal area Pus discharge from rectum Lump or nodule Tenderness at edge of anus Fever Constipation Pain with bowel movements Constant and throbbing pain while sat down
What are signs of perianal abscesses and fistulae?
Seen on rectal exam
Swollen, red, tender lumps at edge of anus
What investigations are done for perianal abscesses and fistulae?
DRE usually normal
STD screening
Proctosigmoidoscopy
performed to exclude associated diagnoses
Transperitoneal US may be a useful adjunct
How do you manage Perianal abscesses and fistulae?
Prompt drainage
Medication for pain relief
ABx not needed unless diabetic or immunosuppressed
Probe is inserted to explore fistulae
Dye inserted into external opening to allow you to find the internal opening
Low fistula - fistuloltomy
High fistula - seton
What are the complications of perianal abscesses and fistulae?
Recurrence
Damage to internal anal sphincter
Incontinence
Persisting pain
What is Peritonitis?
Inflammation of the peritoneal lining of the abdominal cavity. It can be localised to one part of the peritoneum or generalised
What are the types of Peritonitis?
Localised
Primary generalised
Secondary generalised
Primary
What causes localised peritonitis?
Appendicitis
Cholecystitis
DIverticulitis
Salpingitis
What causes Primary generalised peritonitis?
Bacterial infection of the peritoneal cavity without an obvious source
What causes Secondary generalised peritonitis?
Caused by bacterial translocation from a localised focus
Could be non-bacterial due to spillage of bowel contents, bile and blood
What are the risk factors for peritonitis?
Ascites
Nephrotic syndrome
What are the symptoms of Peritonitis?
Usually continuous, sharp, localised exacerbated by movement and coughing
May be vague in those with liver disease and ascites (due to confusion)