Gastrointestinal

Question 1

Common antibiotics responsible for C.diff

Answer 1

Clindamycin
Cephalosporins
Ciprofloxacin
Co-amoxiclav

Question 2

Treatment of non-severe C.diff

Answer 2

Metronidazole PO for 10 days

Question 3

Treatment of severe C.diff

Answer 3

ORAL Vancomycin (as acts topically in gut)
+/- IV metronidazole
10 days

Question 4

Likely pathogens causing intra-abdominal infection

Answer 4

Anaerobes
Coliforms
Enterococci

Question 5

What is the treatment for peritonitis/biliary tract/intra-abdominal infection?

Answer 5

IV Amox Met + Gent

if penicillin allergic –> Vanc Met + Gent

Question 6

Which organism cover does Amoxicillin provide?

Answer 6

Gram +ve (staph, strep + enterococci)

Question 7

Which organism cover does Metronidazole provide?

Answer 7

Anaerobes (e.g. clostridium)

Question 8

Which organism cover does Gentamicin provide?

Answer 8

Gram -ve (e.g. E.coli)

Question 9

Which test is used to diagnose C.diff?

Answer 9

Stool toxin

Question 10

Name the markers of severity in C.diff

Answer 10

Fever
WCC > 15
Ileus, colonic dilatation, toxic megacolon, pseudomembranous colitis
AKI