Gastroenterology

Question 1

What are the zones and toxicity in the liver?

Answer 1

Zone 1 - periportal, best blood supply. Affected by viral hepatitis

Zone 2 - intermediate zone
Yellow fever

Zone 3 - Pericentral vein
Ischaemia, metabolic insults, alcoholic hepatitis

Question 2

What is the cause of ulcers?

Answer 2

NSAIDs - decreased PGe2
Burns (Curling ulcer), hypovolaemia
Brain injury (Cushing ulcer), vagal stimulation

Question 3

Menetrier disease

Answer 3

Hyperplasia of the gastric mucosa due to increased mucous production
Weight loss, anoerxia, vomiting, pain and edema (protein loss)

Question 4

What are the findings in celiac disease?

Answer 4

anti TTG, anti-endomysial, anti-deamidated, gliadin peptide antibodies, villous atrophy, crypt hyperplasia.

Question 5

Liver changes with different conditions

Answer 5

AST > ALT - alcoholic liver disease
AST&raquo_space; ALT - non alcoholic liver disease, drug induced liver disease, ischaemic, viral.