Gastroenterology Flashcards
What is vomiting?
Physical act that results in gastric contents forcefully brought up to and out of the mouth aided by sustained contraction of the abdominal muscles and the diaphragm at a time when the cardia of the stomach is raised and the pylorus is contracted
What is regurgitation?
Effortless expulsion of gastric contents
What is rumination?
Frequent regurgitation of ingested food
What is possetting?
Small volume vomits during or between feeds in otherwise well child
What controls vomiting?
Vomiting centre
Chemoreceptor trigger zone
What neurotransmitters are involved in vomiting?
Histamine (H1), dopamine (D2), serotonin (5-HT3), acetylcholine (muscarinic), neurokinin (substance P)
What are the key precipitants of vomiting?
Toxic material in lumen of GI tract Visceral pathology Vestibular disturbance CNS stimulation Toxins in blood/CSF
What are the different types of antiemetics?
Antihistamines - H2 receptor antagonists, CI acute porphyrias, for motion sickness and PONV treatment
Dopamine D2 antagonist for medication related N&V
Serotonin 5-HT3 antagonists - CI in long QT syndrome, for treatment of PONV
Steroids
Neurokinin receptor antagonist
Name 2 antihistamines for anti sickness treatment and their dose
Cyclizine 50mg
Promethazine 20-25mg
Name 2 dopamine D2 antagonists for anti sickness treatment and their dose
Prochlorperazine 12.5mg
Metoclopramine 20mg over 3 mins, CI 3-4 days post intra-abdominal surgery, obstruction, haemorrhage, perforation, or obstruction and phaeochromocyomas
Droperidol 0.625-1.25mg, CI bradycardia, CNS depression, coma, hypokalaemia, hypomagnesaemia, phaeochromocytoma, long QT syndrome
Name 2 serotonin 5-HT3 antagonists used for anti-sickness treatment and their dose
Ondansetron 4mg
Granisetron 1mg diluted to 5ml given over 30s
Name a steroid used for anti-sickness treatment and their dose
Dexamethasone 3.3-6.6mg
For chemotherapy related N&V
Name a neurokinin receptor antagonist for anti-sickness treatment and its dose
Aprepitant 80mg
For chemotherapy related N&V
What questions are important to ask in a vomiting history?
Bilious/non-bilious (helps localise)
Bloody/non-bloody (inflammation/damage)
Projectile/non-projectile (specific diagnosis)
Age
Febrile/afebrile
Nausea, abdominal pain, distention, diarrhoea, constipation
Headache, changes in vision, polyuria, polydipsia, weight loss - rule out increased ICP or DKA
Hydration status
What are the red flags in a vomiting history?
Meningism
Costovertebral tenderness
Abdominal pain
Any evidence of raised ICP
What is the examinations you should do in a vomiting child?
General - hydration, temp, obs, weight loss, jaundice/pallor
Abdo - distension, scars, tenderness, rigidity, bowel sounds
Neuro - GCS, meningism, neurological deficit
Plot growth
Assessment of hydration status
Evidence of infection
Presence of dysmorphic features, ambiguous genitalia or unusual odours
What are the GI obstruction differentials for vomiting?
Pyloric stenosis Malrotation with intermittent volvulus Intestinal duplication Hirschsprung's disease Antral/duodenal web Foreign body Incarcerated hernia
What other GI problems are differentials for vomiting?
Achalasia Gastroparesis Gastroenteritis Peptic ulcer Eosinophilic oesophagitis/gastroenteritis Food allergy IBD Pancreatitis Appendicitis
What are some neurological differentials for vomiting?
Hydrocephalus SDH Intracranial haemorrhage Intracranial mass Infant migraine
What are some infectious differentials for vomiting?
Sepsis Meningitis UTI Pneumonia Otitis media Hepatitis
What are some metabolic/endocrine differentials for vomiting?
Galactosemia Hereditary fructose intolerance Urea cycle defects Amino and organic acidaemias Congenital adrenal hyperplasia
What are some renal differentials for vomiting?
Obstructive uropathy
Renal insufficiency
What are some toxic differentials for vomiting?
Lead
Iron
Vit A and D
Medications - digoxin, theophylline
What are some cardiac differentials for vomiting?
Congestive HF
Vascular ring
What are some psychiatric differentials for vomiting?
Munchausen syndrome
Child neglect or abuse
Self induced
What are the most common causes of vomiting in children 0-2 days old?
Duodenal or other intestinal atresia
TEF (types A/C)
What are the most common causes of vomiting in children 3 days-1 month old?
Gastroenteritis Pyloric stenosis Malrotation +/- volvulus TEF (types B/D/H) Necrotising enterocolitis Milk protein intolerance CAH IEM
What are the most common causes of vomiting in children 1-36 months old?
Gastroenteritis UTI, pyelonephritis GOR/GORD Ingestion Intussusception Milk protein intolerance
What are the most common causes of vomiting in children 36 months-12 years old?
Gastroenteritis UTI DKA Increased ICP Eosinophilic oesophagitis Appendicitis Ingestion Post-tussive vomiting
What are the most common causes of vomiting in children 12 -18 years old?
Gastroenteritis Appendicitis DKA Increased ICP Eosinophilic oesophagitis Bulimia Pregnancy Post-tussive vomiting
How does malrotation/volvulus present and how is it managed?
Sudden bilious vomit, abdominal distension
As progresses - abdomen can feel peritonitic
Blood per rectum
Metabolic acidosis
Contrast study essential for diagnosis and USS
Urgent surgical referral - division of Ladd bands (Ladds procedure) - return SB to right and LB to left, caecum in LUQ
How does Hirschsprung’s disease/meconium ileus/intestinal atresia present and how is it managed?
Delayed passage of meconium, abdominal distension, bilious vomiting
Surgical referral
How does necrotising enterocolitis present and how is it managed?
Usually pre-term infant, abdominal distension, bilious vomiting
Antibiotics, enteral rest, surgical referral if severe
How does infection present and how is it managed?
May be non-specific or point to source of infection
Investigations to establish cause
May require fluid resuscitation and empirical antibiotic treatment
How does GORD present and how is it managed?
Vomiting associated with feeds
Poor feeds
Cough, wheeze
Step-wise approach
How does food intolerance present and how is it managed?
Vomiting, loose stools, constipation, eczema
Elimination diet
How does pyloric stenosis present and how is it managed?
Progressive projectile vomiting, hypokalaemia, hypochloraemic metabolic acidosis FTT Palpable olive shaped mass Dehydration Fluid and electrolyte replacement prior to surgery NG tube NBM Ramdtedt's pyloromyotomy
How does intussusception present and how is it managed?
Usually 3-36 months of age, colicky abdominal pain, bilious vomiting, red-currant jelly stools
Distended abdomen
Peritonitic
IVI
IVabx
Pneumatic air insufflation or barium enema for reduction
Surgery
How does strangulation hernia/adhesion obstruction present and how is it managed?
Bilious vomiting, abdominal pain
Surgical referral
How does raised ICP present and how is it managed?
Early morning vomiting, bulging fontanelle
CT/MRI
How does acute appendicitis present and how is it managed?
Anorexia, central abdominal pain migrating to RIF, vomiting, pyrexia
Appendectomy
How does pancreatitis present and how is it managed?
Vomiting, abdominal pain
Fluids, analgesia
How does cyclical vomiting syndrome present and how is it managed?
Recurrent episodes of vomiting, child well in between
Exclusion of other causes
How does DKA present and how is it managed?
Polydipsia, polyuria, hyperglycaemia, ketonuria, metabolic acidosis on blood gas
As per national and local guidance
How does medication/alcohol/illicit drug intoxication present and how is it managed?
History of ingestion, recently commenced on new medication
Remove offending substance, supportive care
How is post-operative/pain managed?
Analgesia
Anti-emetics
How do psychiatric causes of vomiting present and how is it managed?
As part of eating disorder
Psychiatry referral
How does pregnancy present and how is it managed?
Weight gain
May not admit to being sexually active
Pregnancy test
How does infection present in older children and how is it managed?
Pyrexia, tachycardia, identifiable source of infection
Antibiotics
What investigations should you do in a child that is vomiting?
Depends on underlying cause, history, presentation, and age of patient
Acute - U&E, stool virology, abdo XR, surgical opinion, exclude systemic disease
Chronic - FBC, ESR/CRP, U&E, LFT, H pylori serology, urinalysis, upper GI endoscopy, abdo USS, small bowel enema, brain imaging, test feed
Cyclic - amylase, lipase, glucose, ammonia
What are the metabolic consequences of vomiting?
K+ deficiency
Alkalosis
Sodium depletion
What are the consequences of vomiting?
Metabolic
Nutritional
Mechanical injuries to oesophagus and stomach
Dental
Oesophageal stricture, Barrett’s, broncho-pulmonary aspiration, FTT, anaemia
What types of mechanical injury can you get to oesophagus and stomach due to vomiting?
Mallory-Weiss
Boerhaave’s syndrome
Tears of short gastric arteries resulting in shock and haemoperitoneum
What is the treatment for vomiting?
Supportive - IV fluids, analgesia, antiemetics
Treat cause - medical/surgical
Pharmacological
What signs may suggest disorders other than GORD?
Bilious vomiting GI bleeding Persistently forceful vomiting New onset of vomiting > 6 months Failure to thrive Diarrhoea Constipation Fever Lethargy Hepatosplenomegaly Bulging fontanelle Macro/microcephaly Seizures Abdominal tenderness or distension Suspected metabolic syndrome
When is reflux normal?
Reflux is normal physiological response in children, often resolves by a year in most children
What is GOR?
Passage of gastric contents into oesophagus, with or w/o regurgitation or vomiting
What is GORD?
Presence of troublesome symptoms and/or complications of persistent GOR
What complications can you get from GORD in children?
Faltering growth Oesophagitis +/- stricture Apnoea, ALTE, SIDS Aspiration, wheeze, hoarseness IDA Seizure-like events, torticolis
How does GORD present in children?
Heart burn
Epigastric pain
What investigations should you do for GORD?
pH Barium swallow and meal Endoscopy Nuclear scintigraphy, tests on ear, lung and oesophageal fluids, USG, combined multiple intraluminal impedance PPI test
What is the management of GORD?
Conservative - Optimise position - Parental education and support - Thicken eg carobel/change feeds - Avoid over feeding - Smaller, more frequent feeds - Weight monitoring - Gaviscon Drugs - antacid, H2 blocker, PPI Surgery - fundoplication