Gastro Enterology

Question 1

PLE
Mecanism of GI protein loss

Answer 1

Lymphatic obstruction
Increased vascular permeability
Mucosal inflammation

Washabau 2019

Question 2

PLE
Affect protein

Answer 2

Most affected : long live protein
Albumin, ceruloplasmin, Ig
Also loss of lymphocytes, iron, calcium

Least affect : short live protein : clotting factors, transferrin, IgE

Washabau 2019

Question 3

PLE
Breed predisposed to primary IL

Answer 3

Yorkshire, SCWT, Lundehund, Maltese, Chinese sharpei

Washabau 2019

Question 4

PLE
Secondary IL

Answer 4

IBD, neoplasia, right congestive failure, lymphatic infection

Washabau 2019

Question 5

PLE
Breed predisposed

Answer 5

Yorkshire, SCWT, Rottweiler, Lundehund, CSP, Maltese, Basenji, GSD, Shiba, Border collie

Washabau 2019

Question 6

PLE
Prevalence of IL in chronic GI disease biopsy
PLE - IBD

Answer 6

50 - 75 % → frequent IL in IBD
IL → lymph leak → inflammation

Washabau 2019

Question 7

PLE
Crypt disease

Answer 7

Yorkshire overrepresented
Dilated cystic lesion of crypt (sloughed cell, debris), aseptic abcess
→ Rupture causing protein loss

Washabau 2019

Question 8

PLE
Biomarker test

Answer 8

CRP : inconsistent (↑ 40% case), negative prognostic indicator

B12 : inconsistent, negative prognostic indicator

Alpha protease inhibitor, calgranulin, calprotectin

Washabau 2019

Question 9

PLE
Nutriments proportion

Answer 9

Fat 10 - 15%
Carbs 55 - 60 %
Protein (high digestive) 25 - 30 %, up to 35% if severely hypoprot

Washabau 2019

Question 10

PLE
Thromboemboly

Answer 10

ATIII loss, vit K loss, vascular compromise, hyperfibrinogenemia, hyperaggregation platelet

6% of dog

Washabau 2019