Gaseous Exchange: Hypoxia and Hyper- and Hypo-Capnia Flashcards

1
Q

Regarding the production of ATP, oxygen is required for (true or false):

A. Glycolysis

A

False. Glycolysis refers to the conversion of glucose to pyruvate, which can proceed by substrate phosphorylation.

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2
Q

Regarding the production of ATP, oxygen is required for (true or false):

β oxidation of fatty acids

A

True

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3
Q

Regarding the production of ATP, oxygen is required for (true or false):

Conversion of amino acids to acetyl CoA

A

True

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4
Q

Regarding the production of ATP, oxygen is required for (true or false):

Krebs Cycle

A

True. High energy reduced compounds need to be oxidised in the electron transfer chain to enable the Krebs cycle to continue.

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5
Q

Regarding the production of ATP, oxygen is required for (true or false):

Electron transfer chain

A

True. Oxygen is the final step accepting electrons.

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6
Q

How much energy is produced from the aerobic metabolism of each glucose molecule?

A. 38 ATP
B. 2 ATP
C. 19 ATP
D. 6 ATP
E. 22 ATP

A

A.

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7
Q

The followings shifts the O2 dissociation curve to the right (true or false):

Increase in pH

A

False. An increase in pH, shifts the curve to the left, increasing the affinity of Hb for O2.

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8
Q

The followings shifts the O2 dissociation curve to the right (true or false):

Increase in [H+]

A

True

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9
Q

The followings shifts the O2 dissociation curve to the right (true or false):

Increase in temperature

A

True

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10
Q

The followings shifts the O2 dissociation curve to the right (true or false):

Increase in 2,3-DPG

A

True

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11
Q

The followings shifts the O2 dissociation curve to the right (true or false):

Increase in Hb

A

False

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12
Q

These responses are mediated by the peripheral chemoreceptors (true or false):

Ventilatory response to hypoxia

A

True. The peripheral chemoreceptors respond to changes in PO2, PCO2 or [H+]. Stimulation causes both respiratory and cardiovascular changes.

The central chemoreceptors respond to changes in PCO2, however this is enhanced by the detection of hypoxia by the peripheral receptors.

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13
Q

These responses are mediated by the peripheral chemoreceptors (true or false):

Ventilatory response to hypotension

A

True. The effect is probably due to stagnant hypoxia at the peripheral chemoreceptors.

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14
Q

These responses are mediated by the peripheral chemoreceptors (true or false):

Circulatory response to hypoxia

A

True. The peripheral chemoreceptors respond to changes in PO2, PCO2 or [H+]. Stimulation causes both respiratory and cardiovascular changes.

The central chemoreceptors respond to changes in PCO2, however this is enhanced by the detection of hypoxia by the peripheral receptors.

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15
Q

These responses are mediated by the peripheral chemoreceptors (true or false):

Ventilatory response to hypercapnia

A

True

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