Gas Laws Flashcards
Henry’s Law
- the solubility of a gas in a liquid is directly proportional to the partial pressure of the gas
Application of Henry’s Law
- Using the partial pressure of O2 or CO2 to find out how much O2 and CO2 is dissolved in blood.
- multiple the PaO2 and PaCO2 by the coefficient to find Solubility
- increasing FiO2
- over-pressuring the vaporizer
Solubility coefficient for oxygen
0.003
Solubility coefficient of CO2
0.067
Graham’s Law
- The rate a molecule diffuses at is inversely related the square root of its molecular weight
- smaller molecules diffuse faster
Application of Graham’s Law
-Nitrous oxide diffusing into air filled cavities
(nitrous diffusing into endotracheal tube cuffs)
-apneic oxygenation
(The continual diffusion of oxygen in the blood strictly from concentration gradient from the ventilator circuit into the alveoli)
Fick’s Law
- The rate of diffusion of a gas across a semipermeable tissue is related to :
1) partial pressure of the gas (directly related)
2) the membrane solubility of the gas (directly related)
3) the area of the membrane (directly related)
4) membrane thickness (indirectly related)
5) molecular weight (indirectly related)
Application of Fick’s Law
-2nd gas effect of nitrous oxide
Pressure Equivalents
1atm = 1bar = 760 mmHg = 760 torr = 14.7 psi = 1020 cm H2O = 100KpA
Boyles Law
P1 * V1 = P2 * V2
Example of Boyle’s Law
- ventilating with reservoir bag
- spontaneous breathing
- bellows on vent
Charles Law
V1/T1 = V2/T2
Application of Charles Law
-
Guy Lussac’s Law
P1/T1 = P2/T2
Application of Guy Lussac’s Law
-Gas leaving the E-cylinder creates a frost on the outside of it
Universal gas law
PV = nRT
Application of Universal Gas Law
- as an e-cylinder of a tank empties, the pressure decreases
Avogadro #
6.02 E23
1 mole of any substance occupies how much space in L
22.4L
Avogadro’s Law
V1/n1 = V2/n2
Application of Avogadro’s Law
- vaporizer calibration
Ex: molecular weight of sevoflurane is 200g. 200g = 1mole of sevo. That would take up 22.4L due to ideal gas law. If we put 20g of sevo in the vaporizer how much space would it take up?
20g/1 * 1mole/200g * 22.4L/1mole = 2.24L
Dalton’s Partial Pressure Law
-the total pressure of a gas mixture of the sum of the partial pressures of each gas component
Application of Daltons Law
- If air is 21% oxygen and 79% nitrogen what is the Partial pressure of nitrogen at 1 atm?
760mmHg * .79 = 600.4mmHg
Critical Temperature
- if the ambient temperature is above the critical temperature, no amount of pressure could liquify said gas
Critical temperature of oxygen
-119 degrees Celsius
Critical temp of nitrous oxide
39.5 degrees Celsius
Room temp
~20 degrees Celsius
ADIABATIC cooling
- change in temperature of matter without gaining or losing heat (energy)
- N2O cylinder cracked and open fully, frost forms on cylinder opening
Joule Thompson Effect
- the expansion of gas causes cooling
Application of the Joule Thompson Effect
-as gas leave the cylinder, the expansion cools the surrounding area, causing condensation of moisture on the cylinder
Pouseuille’s Law
- Flow is related to: Pressure gradient across length of tube (direct) Radius4 (direct) Length (indirect) Viscosity (indirect)
Application of Pousielle’s Law
- IV flow
- airway (inflammation of the cricoid)
- laminar flow in a blood vessel
- Thorpe Tubes at low flow
When flow is laminar what determines flow?
Viscosity
What flow is turbulent what determines flow?
- density
- ex: heliox in narrow airways
Reynolds number >2000 means?
Turbulent flow
How can you change flow from laminar to turbulent?
-bend in tube
Bournoulli’s Theorem
- relates how pressure and velocity interact
- narrow diameter = decreased lateral wall pressure = increased speed
- wider diameter = increased lateral wall pressure = decreased speed
Venturi Effect
- as the diameter of the tube decreases, velocity increases, as velocity increases, the pressure surrounding the flow DROPS
Applications of Bernoulli and Venturi
- nebulizers
- jet ventilation
Beers Law
- the absorption of a gas is determined by the:
Absorption rate of the gas (direct)
Concentration of the gas (direct)
Thickness (inverse)
Application of Beers Law
-pulse ox
Law of LaPlace
- tension is related to
pressure (direct)
radius (indirect)
Application of LaPlace Law
- alveoli
- aneurysm
Ohm’s Law
Resistence = potential / current
Voltage = current / resistance
Application of Ohm Law
-transducers
2% lidocaine = ? mg/mL
20 mg/mL
1% lidocaine = ? mg/mL
10mg/mL
7.5% bupivicaine = ? mg/mL
7.5mg/mL
1:100,000 Epinephrine = ? mcg/mL
10mcg/mL
1:1000 neostigmine = ? mg/mL
1mg/mL
1:10,000 Epinephrine = ? mcg/mL
10mcg/mL