Gas exchange ๐ Flashcards
Describe type I pneumocytes
- Cover 70% of the internal surface area of each alvelous.
- Thin, flattened epithelial cells.
- Amitotic and unable to replicate
- Connected by occluding junctions which prevent leakage
What is the function and adaptations of type I pneumocytes
Gas exchange. Theyโre extremely thin to make them:
1. More permeable
2. Shorter diffusion distance
What is the route of air during ventilation?
Nose/mouth
Nasal cavity
Larynx
Epiglottis
Trachea
Bronchi
Bronchioles
Alveoli
Process of inspiration regarding body/organs
As you inhale the external intercostal muscles contract (internal intercostal relax) which causes the ribcage to move up and out, and the diaphragm flattens downward. Abdominal muscles relax. Through the expansion the pressure decreases and the volume increases. Decrease in pressure causes the air to flow in, causing the lungs to inflate and gas exchange to happen in the alveoli.
Process of expiration regarding body/organs
The internal intercostal muscles contract and the external intercostal muscles relax, causing ribcage to move down and inwards. Abdominal muscles contract, pushing diaphragm up. Pressure increases, volume decreases, air is forced out.
Describe type II pneumocytes
Dense, large cells (cuboidal or round) full of surfactant concentrated in the alveoli septum.
Diffusion
Movement of gas from high to low concentration gradient (down conc. grad.) which makes ventilation like actually useful
Function of type II pneumocytes
Secrete surfactant on inner surface of alveolus for moisture to:
1. Aid diffusion of gases
2. Prevent walls from sticking together and thus collapsing
They also
* Divide to form type I pneumocytes in case of damage to epithelium
What happens in emphysema
Tobacco gets into lungs. Leukocytes release elastase which breaks down the connective tissue - protein elastin - in lungs. Loses lung elasticity in alveoli and in bronchiol causes collapse as they are not turgid anymore. When person inhales again, the air going in causes the already air-filled alveoli to forcefully expand, destroying the alveolar membrane (gas exchange medium). Large air pockets in lungs.
Define emphysema
Disease which causes inflammation of alveoli. Affects area to volume ratio.
Emphysema treatment
Stop smoking lmao. Oxygen therapies. Bronchodilators.
Spirometer
Instrument to measure volume of air entering and leaving lungs
Tidal volume
Volume of air inspired or expired in a single breath during regular breathing
Explain process of gas exchange in alveoli
- Oxygen diffuses into blood, carbon dioxide diffuses out of blood.
- Air in the alveolus is higher in Oxygen.
- This causes a concentration gradient which provokes diffusion.
- Concentration gradient is maintained by blood flow.
- Large surface area created by many alveoli for more efficient diffusion
- Rich supply of capillaries allows efficient exchange.
- Type I pneumocytes thin, more permeable, which makes diffusion faster.
What does surfactant do
- Reduces surface tension which prevents walls from sticking together and collapsing
- Allows more efficient gas exchange by providing medium
+ kills or prohibits dissemination of pathogens