Gametogenesis and Fertilization Flashcards

1
Q

primordial germ cells

A
  • progenitors of gametes

- from yolk sac endoderm, migrate to genital ridge and become indifferent gonad

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2
Q

intermediate mesoderm

A

-urogenital organs: leydig cells, sertoli cells, follicular cells, ovary, testis, ducts, uterus

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3
Q

urogenital sinus endoderm

A

-terminal internal parts of genital organs: vesicular, prostate and bulbourethral glands

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4
Q

Mullerian (paramesonephric) ducts

A
  • develop into fallopian tubes, uterus, cervix

- in male they disappear under the influence of anti-paramesonephric duct hormone

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5
Q

prepuberal testis

A
  • seminiferous cords consisting of: sertoli cells, primordial germ cells (stem cells for spermatogenesis-stay dormant until puberty)
  • inactive interstitial cells of leydig
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6
Q

cryptochidism

A

testes fail to descend into scrotum, inherited as a sex-limited autosomal recessive trait

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7
Q

types of cryptorchidism

A
  • unilateral

- bilateral: sterile but has normal sexual behavior

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8
Q

scrotal hernia

A

type of inguinal hernia=congenital weakness in the abdominal wall

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9
Q

primitive sex cells

A

spermatogonia, oogonia- have complete DNA complement.

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10
Q

spermatogonia and oogonia Mitosis

A

results in more spermatoginia and oogonia

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11
Q

spermatocye and oocyte meiosis

A

insure variation and provide 1/2 of chromosomes (haploid number) both in male (1N) and female (1N) sex cells (gametes)

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12
Q

fertilization

A

joining of sex cells, create zygote, restores DNA complement (2N) initiates cleavage

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13
Q

mitosis

A

results in formation of 2 daughter cells each having DIPLOID set of chromosomes, same number as in the mother cell

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14
Q

Meiosis

A

comprised of 2 meiotic divisions, results in daughter cells which have half the parental number of chromosomes (haploid), called gametes

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15
Q

goals of meiosis

A
  • reduction of diploid set chromosomes into haploid gametes
  • exchange of genetic material between male and female chromatids in prophase of meiosis (crossing over)
  • results in 4 daughter cells with 4 different genetic makeups
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16
Q

common features of gametogenesis

A
  • multiplication of spermatogonia and oogonia
  • meiosis
  • extensive morphological differentiation
  • incapacity of surviving for long if ferrtiization does not occur
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17
Q

characteristics of sperm

A
  • continually renewed
  • one spermatocyte produces 4 sperm
  • initial large cell results in small cells
  • motile cells
  • x or y sex chromosomes
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18
Q

characteristics of ovum

A
  • all oocytes present at birth
  • one oocyte produces 1 ovum and 2-3 polar bodies
  • initial small cell grows to large cell
  • immobile
  • x chromosome only
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19
Q

oogenesis

A

occur in ovary
1. oogonia-prenatal mitosis and differentiation
2. all are primary oocytes (4N) arrested in meiosis 1 until puberty
-at ovulaton, meiosis 1 is completed except in dogs and mares
3. secondary oocyte awaits fertilization in uterine tubes
-meiois 2 completed on sperm contact
result is ovum (1N) and 2nd polar body (2N)

20
Q

ovulation

A

results from hormone influence on folliculogenesis at puberty

21
Q

folliculogenesis: primordial (resting) follicles

A

oocyte1 + single layer of squamous follicular cells

22
Q

folliculogenesis: primary follicles

A

activated or growing follicles, zona pellucida forms

23
Q

folliculogenesis:secondary follicles

A

secretory/antral follicles, fluid filled spaces are formed among the granulosa cells

24
Q

folliculogenesis: tertiary mature (Graafian) follicle

A

one antrum containig liquor folliculi, have eccentric cumulus oophorus, contain primary oocyte

25
zona pellucida
acts as immunologic protective barrier for developing egg and early embryo
26
corpus hemorrhagicum
after ovulation the follicular space fills with blood and clots, will be replaced by luteal calls and become corpus luteum
27
corpus luteum
yellow body, produces progesterone and some estrogen - granulosa luteal cells: large - theca luteal cells: small
28
progesterone
helps maintain the pregnancy, stimulate mammary development, and locally down regulates the immune system
29
corpus albicans
corpus luteum regresses during diestrus, connective tissue scar
30
atrectic follicle
follicle that is not selected to complete maturation, undergo programmed destruction, common
31
ovulation
oocyte departs the ovary and leave behind corpus hemorrhagicum that becomes the corpus luteum of thecal and granulosa cells
32
spermatogenesis
- spermatogonium mitosis: differentiate - primary spermatocyte: meiosis 1 (crossover) - 2 secondary spermatocytes: meiosis 2 - 4 sermatids do not divide but undergo spermiogenesis (metemorphosis) - 4 spermatozoa
33
functions of sertoli cells
- activated by FSH - secrete AMH during fetal development to inhibit uterus formation - secrete inhibin and activins after puberty to regulate FSH secretion from pituitary - secrete androgen binding protein (ABP) to bind testosterone increase concentration in seminiferous tubules and stimulate spermatogenesis
34
sperm cell maturation
spermatogonia (2N) --> spermatocytes: primary (4N) undergo st meiosis to secondary (2N) undergo 2nd meiosis-->spermatids (1N) undergo metamorphosis to spermatozoa
35
round spermatid
undergoes metamorphosis to elongated spermatids
36
sperm head
nucleus and acrosome
37
sperm head shape
- ruminants: disc like - man, stallion: pear shaped - rodents: hook like - guinea pig: spoon like - birds: filiform
38
axonema
core of cilia & sperm flagellum (tail)
39
structure of axonema
-derived from modified centriole -pair of central microtubles + outer ring of 9 doublets with dynein arms -each doublet has a microtuble A with dynein arms + an incomplete microtubule B
40
characteristics of spermatogenesis
- continuous process: throughout the year except for seasonal breeders - highly organized process, fixed length of time - takes place in orderly waves - very sensitive to: temperature, x ray irradiation, nutrition, infection & non-infectious diseases, stress, drugs
41
spermatogenesis vs oogenesis: sperm
- spermatogonia remain dormant until puberty, the proliferate by mitotic division - meiosis completed within testis - each spermatogonium give rise to multiple - spermatids undergo metamorphosis - spermatogenesis may continue throughout the whole life of the animal
42
spermatogenesis vs oogenesis: oogenesis
- complete their proliferation in the early embryonic stage - by birth all oogonia entered meiosis 1 but development arrested until puberty - one oocytes give rise to one ovum - ova do not undergo metamorphosis - meiosis is completed in fallopian tube - oogenesis stops after overy exhausted of germ cells
43
fertilization-sperm
-capacitation: occurs in uterine environment, gain ability to fertilize the oocyte -acrosome reaction: release acrosomal enzymes to digest through zona pellucida sperm contacts oocytes -fusion of sperm plasma membrane with plasma membrane of oocyte
44
capacitation and acrosome reaction
plasma membrane over acrosome is destabilized and breaks down together with outer acrosomal membrane, acrosomal enzymes are released
45
fertilization-ovum
- cortex of oocytes below oolemma contains cortical granules - sperm contact with oocyte plasma membrane causes release of proteases which modifies zona pellucida - zona pellucida is then a barrier to other sperm penetration
46
pronuclei
nuclear material of sperm and ootid
47
syngamy
union of male and female pronuclei