Gall bladder.3. Calcular obstructive jaundice Flashcards
STONES IN THE BILE DUCTS
- Alternative name
- ORIGIN
- SEQUELAE
Alternative name for STONES IN THE BILE DUCTS
Choledocholithiasis
ORIGIN of STONES IN THE BILE DUCTS
(1) Gall bladder: (Commonest)
2) Primary duct stones: (Not common
Gall bladder in ORIGIN of STONES IN THE BILE DUCTS
- Incidence
2. Pathogenesis
Incidence of Gall bladder in ORIGIN of STONES IN THE BILE DUCTS
Commonest
Pathogenesis of Gall bladder in ORIGIN of STONES IN THE BILE DUCTS
CBD stones are migrating from G.B.
Primary duct stones in ORIGIN of STONES IN THE BILE DUCTS
- Incidence
2. Pathogenesis
Incidence of Primary duct stones in ORIGIN of STONES IN THE BILE DUCTS
Not common
Pathogenesis of Primary duct stones in ORIGIN of STONES IN THE BILE DUCTS
2ry to infestation of the biliary tree by Ascaris & Clonorchis sinensis.
SEQUELAE of STONES IN THE BILE DUCTS
- No effect : A small stone in the CBD without obstruction.
- Passed stone.
- Calcular obstructive jaundice.
Pathogenesis of Passed stone in SEQUELAE of STONES IN THE BILE DUCTS
Passed to the duodenum
Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
- CLINICAL PICTURE
- SEQUELAE & COMPLICATIONS
- DIFFERENTIAL DIAGNOSIS
- INVESTIGATIONS
- TREATMENT
CLINICAL PICTURE of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
- Symptoms
2. Examination
Symptoms in CLINICAL PICTURE of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
- The patient gives history of CCC with pain & fatty dyspepsia.
- Jaundice
- Charcot’s triad
- Reynold’s pentad
Jaundice in Symptoms in CLINICAL PICTURE of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
- Course
- Degree
- Associations
- Note on the relation between size of stone and jaundice
Course of Jaundice in Symptoms in CLINICAL PICTURE of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
- usually Painful
- Slowly progressive
- Fluctuating
Degree of Jaundice in Symptoms in CLINICAL PICTURE of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
usually does not reach a severe degree
Associations of Jaundice in Symptoms in CLINICAL PICTURE of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
Associated with dark frothy urine & pale stools
The reason why urine is dark in Associations of Jaundice in Symptoms in CLINICAL PICTURE of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
due to presence of direct bilirubin in urine
The reason why urine is frothy in Associations of Jaundice in Symptoms in CLINICAL PICTURE of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
due to presence of bile salts in urine
Note on the relation between size of stone and jaundice in Jaundice in Symptoms in CLINICAL PICTURE of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
- There is no relation between the size of the stone and the development of jaundice
- A tiny stone impacted in the ampulla may cause jaundice, while large stone in a dilated CBD may not cause obstruction
Charcot’s triad in Symptoms in CLINICAL PICTURE of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
- List of symptoms
2. Pathogenesis
List of symptoms of Charcot’s triad in Symptoms in CLINICAL PICTURE of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
Recurrent attacks of :
- Pain.
- Jaundice.
- Fever and rigors.
Pathogenesis of pain in List of symptoms of Charcot’s triad in Symptoms in CLINICAL PICTURE of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
Right answer: As the patient already having CCC or due to cholangitis
Wrong answer (department) due to biliary colic
Pathogenesis of Charcot’s triad in Symptoms in CLINICAL PICTURE of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
Due to superadded cholangitis
Reynold’s pentad in Symptoms in CLINICAL PICTURE of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
- Charcot’s triad
- Septic shock.
- Altered mental status.
Examination in CLINICAL PICTURE of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
- Jaundice in not severe.
- +ve Murphy’s sign.
- The gallbladder is not palpable
The reason why the gallbladder is not palpable in Examination in CLINICAL PICTURE of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
- Since it is fibrosed & shrunken
2. Due to long standing CCC “Courvoisier’s Law”.
SEQUELAE & COMPLICATIONS of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
A. Effects on the liver
B. Effects on the coagulation factors
C. Hepato-renal failure
Effects on the liver in SEQUELAE & COMPLICATIONS of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
- Hydro-hepatosis
- Ascending cholangitis
- White bile
- 2ry biliary cirrhosis in long standing cases.
Definition of Hydro-hepatosis in Effects on the liver in SEQUELAE & COMPLICATIONS of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
Dilatation of intrahepatic biliary radicles
Ascending cholangitis in Effects on the liver in SEQUELAE & COMPLICATIONS of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
- Alternative name
2. Pathogenesis
Alternative name for Ascending cholangitis in Effects on the liver in SEQUELAE & COMPLICATIONS of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
Cholangio-hepatitis
Pathogenesis of Ascending cholangitis in Effects on the liver in SEQUELAE & COMPLICATIONS of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
due to 2ry infection.
White bile in Effects on the liver in SEQUELAE & COMPLICATIONS of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
- Pathogenesis
2. Significance
Pathogenesis of White bile in Effects on the liver in SEQUELAE & COMPLICATIONS of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
In severe cases liver cells stop to secrete bile while bile ducts will continue to secrete pale yellow mucous (white bile).
Significance of White bile in Effects on the liver in SEQUELAE & COMPLICATIONS of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
indicates severe liver damage.
Effects on the coagulation factors in SEQUELAE & COMPLICATIONS of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
Bile salts fail to reach the intestine )> failure of absorption of fat soluble vitamins especially Vit K )> Hypoprothrombinemia
Hepato-renal failure in SEQUELAE & COMPLICATIONS of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
- Alternative name
2. Pathogenesis
Alternative name for Hepato-renal failure in SEQUELAE & COMPLICATIONS of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
Renal shut down
Pathogenesis of Hepato-renal failure in SEQUELAE & COMPLICATIONS of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
- Absence of bile salts in the intestine leads to bacterial overgrowth )> bacterial transclocation
which may fail to be filtered by hepatic “Kupffer cells”. - This gram -ve endotoxemia causes renal cortical necrosis & acute renal failure.
Pathogenesis of renal cortical necrosis & acute renal failure in Pathogenesis of Hepato-renal failure in SEQUELAE & COMPLICATIONS of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
Shift of blood from cortex to medulla
DIFFERENTIAL DIAGNOSIS of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
Malignant obstructive jaundice
Difference between Calcular obstructive jaundice and Malignant obstructive jaundice in DIFFERENTIAL DIAGNOSIS of Calcular obstructive jaundice in SEQUELAE of STONES IN THE BILE DUCTS
- Age and gender
- Pain
- Course of jaundice
- Degree of jaundice
- Palpation of gall bladder
- Murphy’s sign