GAGs

Question 1

Hyaluronan

Answer 1

Localization - synovial fluid, vitreous humor, loose CT, healing CT, cartilage
Comments - forms large PG aggregates

Question 2

Chrondroitin sulfate

Answer 2

Localization - cartilage, bone, heart valves, tendons, ligaments
Comments - most abundant GAG, increased w/ compression

Question 3

Heparan sulfate

Answer 3

Localization - basement membranes, cell surfaces

Comments - interacts w/ numerous proteins

Question 4

Heparin

Answer 4

Localization - intracellular granules in mast cells lining arteries

Question 5

Dermatan Sulfate

Answer 5

Location - skin, blood vessels, tendons, ligaments

Comments - increased w/ tensile forces

Question 6

Keratan Sulfate

Answer 6

Location - cornea, bone, cartilage

Comments - forms part of large PG aggregates in cartilage

Question 7

Chondronectin

Answer 7

Glycoprotein

Attaches chondrocytes to type II collagen

Question 8

Fibronectin

Answer 8

Glycoprotein

Interacts w/ cell-surface receptors, blood-clotting, components, denatured collagen, cytoskeleton, GAGs

Question 9

Lubricin

Answer 9

Glycoprotein

Adheres to articular surface to provide boundary lubrication

Question 10

Aggrecan

Answer 10

PG
Found in numerous chains of KS & CS
Binds to hyaluronan
Creates osmotic swelling pressure in cartilage by attracting water